DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14710 and ZNF446

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_060378.1	Gene:	ZNF446 / 55663	HGNCID:	21036	Length:	450	Species:	Homo sapiens

Alignment Length:	178	Identity:	50/178 - (28%)
Similarity:	66/178 - (37%)	Gaps:	46/178 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 MSSAPSPHPSFKMDKQKPGRPRKP----DAELKFKRKDINAKERGNQPKCKEEEKFMCILCGNVF 271
            :|.|.:|.|:.     :||.|..|    .||.:.            :|.....:.:.|..||..|
Human   294 LSGAATPAPTV-----RPGTPPVPTQPTPAETRL------------EPAATPRKPYTCEQCGRGF 341

  Fly   272 YKKSVFTAHMMTH---------------SEYKPHQCEICNKSFRQMGELRAHIRRH-TGDRPYKC 320
            ..||||..|..||               |..||.|.|:.         ...|.||. ||.|.|.|
Human   342 DWKSVFVIHHRTHTSGPGVQSPGLATGESTEKPPQGEVA---------FPHHPRRSLTGPRSYPC 397

  Fly   321 MYCDRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSH 368
            ..|...|..:|:.|.|.:.||..|.:.|.:||:.|...:.|..|...|
Human   398 EECGCSFSWKSQLVIHRKSHTGQRRHFCSDCGRAFDWKSQLVIHRKGH 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071
		COG5048	<261..395	CDD:227381	39/124 (31%)
		C2H2 Zn finger	264..284	CDD:275368	9/19 (47%)
		zf-C2H2	290..312	CDD:278523	4/21 (19%)
		C2H2 Zn finger	292..312	CDD:275368	3/19 (16%)
		zf-H2C2_2	304..327	CDD:290200	9/23 (39%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..357	CDD:290200	8/21 (38%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..395	CDD:275368
ZNF446	NP_060378.1	SCAN	22..137	CDD:128708
		SCAN	22..110	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..155
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..205
		KRAB	<209..237	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..331		11/53 (21%)
		C2H2 Zn finger	334..354	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..389		9/43 (21%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	410..432	CDD:290200	8/21 (38%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23226
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100