DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14710 and CG31365

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_732827.1	Gene:	CG31365 / 42736	FlyBaseID:	FBgn0051365	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	639	Identity:	128/639 - (20%)
Similarity:	201/639 - (31%)	Gaps:	255/639 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CRICLGDFEESQMICLFGDKGESDLR--KKLELCCRIRVRQSPQLPEKACNSCCEFVQMWFNFRQ 72
            ||:||.:.:::..|.   |:.::.|.  .:|..|..:..:.:..||::.|..|...::..|.|||
  Fly    14 CRLCLKEHQDAYAIF---DEDDTQLSIPVRLMACVALDAKATDTLPKRICQECRYQLEKSFLFRQ 75

  Fly    73 MC-----------------LNSQVY----------------------------------W----- 81
            .|                 ..|:|:                                  |
  Fly    76 RCQWAEKKLRKHIRLLGLGKRSRVFSKDPDDYDEDELEFEDSIAFIEVQDKVRKLEDEKWREDFK 140

  Fly    82 --------------------------------------------------------ETSSSERPE 90
                                                                    |.|...|.|
  Fly   141 EEQAAEMHKRLVKSRLELRAKLTTELRKELAEEVRSEVRKELAEEVRSQVRDDLRNEVSEDIRKE 205

  Fly    91 ALAQASDAEYMLYLYENLHLKLG-----------TENQEKEE------------------ITAIE 126
            .||... .|..:||.|.   |.|           |:.|.||:                  :.|..
  Fly   206 QLAMLL-GELEVYLTEK---KAGRWESLDGSEPETKPQVKEDASPSRSKTKALPKRRPSLVDANL 266

  Fly   127 EGDEQQEDQSQE--VLDFNGFIINES------IEEDEEPNTESPEQIL--------ISHMDS--- 172
            :..|.::|..:|  :|..|....|.|      :|.|||...||.|...        :.|.|:
  Fly   267 KATEARKDAKEEEFILGCNTDPANNSDVNIDGLELDEEVPAESGEDFREINMVGSDVVHTDNGEI 331

  Fly   173 YV------DDQQMEEL-------------------IDDKGELVEELSNANTFYEVEYGDEELLMS 212
            |:      :||..:..                   |...||..||:.:...|   ..|:|.....
  Fly   332 YIINSASSEDQNQDSTPEFDQDNGITSYNIKEDGEIQFSGEKPEEIEDVVVF---NLGEEISQEQ 393

  Fly   213 SAPSPHPSF--------KMDKQKPGRPRKPDAELKFKRKDINAKERGNQPK----CKEEEKFMCI 265
            ...|.|.:.        ..|:|.|.: ||..:||.||:     :....|||    ....:.|.|.
  Fly   394 QVFSFHENVIIVEKEQNDRDEQTPLK-RKRSSELVFKQ-----ESSCPQPKTGRITDTVKSFQCH 452

  Fly   266 LCGNVFYKKSVFT----------------------------------AHMMTHSEYKPHQCEICN 296
            ||...|..:.:.|                                  .||:.|:..||.:|..|.
  Fly   453 LCPVAFPTQKLLTRHHNTHIKGLKSGKGGTLKCPSCALQLSCASSLKRHMIIHTGLKPFKCSECE 517

  Fly   297 KSFRQMGELRAHIRRHTGDRPYKCMYCDRHFYDRSERVRH-ERVHT-NTRPYACQECGKTFTHTA 359
            .||.|...|:.|:..|||.:.::|..|...|..:|...:| .|||. |:|.:.|..|.::|.|.:
  Fly   518 LSFSQREVLKRHMDTHTGVKRHQCPQCSSCFAQKSNLQQHIGRVHMGNSRTHKCHLCHRSFNHVS 582

  Fly   360 ILKNHILSHSAQKNYNCGICCKSFTLLHQLKAHLQTLTH--RNKMEQTIPSSPE 411
            .|..|:::| |...::|..|.:.|.....::.|:.|: |  :||:...|..:.|
  Fly   583 GLSRHLVTH-AGVMFSCKQCGRQFNDRSAVQRHVTTM-HKVKNKLTDYISETNE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	21/186 (11%)
		COG5048	<261..395	CDD:227381	43/169 (25%)
		C2H2 Zn finger	264..284	CDD:275368	7/53 (13%)
		zf-C2H2	290..312	CDD:278523	7/21 (33%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..327	CDD:290200	7/22 (32%)
		C2H2 Zn finger	320..340	CDD:275368	6/20 (30%)
		zf-H2C2_2	335..357	CDD:290200	9/23 (39%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..395	CDD:275368	4/18 (22%)
CG31365	NP_732827.1	zf-AD	13..86	CDD:214871	18/74 (24%)
		vATP-synt_E	109..>244	CDD:304907	17/138 (12%)
		RRF	<161..222	CDD:294170	10/64 (16%)
		zf-C2H2_8	454..530	CDD:292531	14/75 (19%)
		C2H2 Zn finger	485..505	CDD:275368	2/19 (11%)
		zf-H2C2_2	497..522	CDD:290200	9/24 (38%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	526..550	CDD:290200	8/23 (35%)
		C2H2 Zn finger	541..562	CDD:275368	6/20 (30%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	598..617	CDD:275368	4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.980