DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14710 and CG4854

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_650860.1	Gene:	CG4854 / 42391	FlyBaseID:	FBgn0038766	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	399	Identity:	111/399 - (27%)
Similarity:	179/399 - (44%)	Gaps:	94/399 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQCRICLGDFEESQMICLFGDKGESDLRKKLELCCRIRVRQSPQLPEKACNSCCEFVQMWFNFRQ 72
            |:|||||...::..::     ..|.|...|::.|..:.:.:||..|.:.|.||...::.....|.
  Fly    10 LKCRICLVQPKDESLM-----PTEPDFPDKIKRCTGVELSESPDWPNRICTSCALLLRAALKLRS 69

  Fly    73 MCLNSQVYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEEGDEQQEDQSQ 137
            :|                   |.::.:              .:.|:.:||......|||:..:..
  Fly    70 LC-------------------QQTEKD--------------LKEQKLQEINIEIVHDEQETKKKT 101

  Fly   138 EVLDFNGFIINESIEEDEEPNTESPEQILISHMDSY-VDDQQMEELIDDKGELV--EELSNANTF 199
            |..|.:.   ||:...|.|...|        ::||| |..:..|::.....|||  |...:|
  Fly   102 ESRDLSK---NEATGSDSELEYE--------YLDSYDVTLESSEDVACSADELVSIEPAISA--- 152

  Fly   200 YEVEYGDEELLMSSAPSPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKERGNQPKCKEEEKFMC 264
                  .||.:.|.:|.|                    :.|:.:|..           :...|.|
  Fly   153 ------PEESVYSLSPKP--------------------VTFEDEDSG-----------QAASFTC 180

  Fly   265 ILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRRHTGDRPYKCMYCDRHFYD 329
            .:|.||:.::...|.||..||..|||:||||:|.|||..:|..|:..|||:|||||.|||..|.|
  Fly   181 NICNNVYSERVKLTNHMKVHSAKKPHECEICHKRFRQTPQLARHMNTHTGNRPYKCDYCDSRFAD 245

  Fly   330 RSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKSFTLLHQLKAHLQ 394
            .|.|::|:|:|||.|||.|:.|.::|.::.:|:.|:.:|:.::.::|..|.|||:.||...:|.:
  Fly   246 PSTRIKHQRIHTNERPYKCEFCSRSFGYSNVLRVHLKTHTGERPFSCQYCQKSFSQLHHKNSHEK 310

  Fly   395 TLTHRNKME 403
              :|:...|
  Fly   311 --SHKRTKE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	17/73 (23%)
		COG5048	<261..395	CDD:227381	60/133 (45%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-C2H2	290..312	CDD:278523	11/21 (52%)
		C2H2 Zn finger	292..312	CDD:275368	10/19 (53%)
		zf-H2C2_2	304..327	CDD:290200	13/22 (59%)
		C2H2 Zn finger	320..340	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..357	CDD:290200	11/21 (52%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		C2H2 Zn finger	376..395	CDD:275368	8/18 (44%)
CG4854	NP_650860.1	zf-AD	12..>57	CDD:285071	13/49 (27%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		zf-H2C2_2	193..217	CDD:290200	14/23 (61%)
		COG5048	201..>258	CDD:227381	32/56 (57%)
		C2H2 Zn finger	208..228	CDD:275368	10/19 (53%)
		zf-H2C2_2	221..244	CDD:290200	13/22 (59%)
		C2H2 Zn finger	236..256	CDD:275368	10/19 (53%)
		zf-H2C2_2	251..273	CDD:290200	11/21 (52%)
		C2H2 Zn finger	264..284	CDD:275368	5/19 (26%)
		zf-H2C2_2	277..301	CDD:290200	8/23 (35%)
		C2H2 Zn finger	292..312	CDD:275368	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C1GA
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006293
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23226
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.960