DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14710 and Zif

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	114/408 - (27%)
Similarity:	178/408 - (43%)	Gaps:	73/408 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CRICLGDFEESQMICLFGDKGESDLRKKLELCCRI---RVRQSPQLPEKACNSCCEFVQMWFNFR 71
            ||:||...|..|.:....::||....:.|.....:   .:.....:|:..|.||...:.|.:.||
  Fly    10 CRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNMAYQFR 74

  Fly    72 QMCLNSQVYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEE---GDEQ-Q 132
            :..|..|:..|....|    |....:::.|:...|:     |::.|..||:..:||   |:|: |
  Fly    75 EKALRKQMEIEEYCRE----LGLLDESDVMMIKEED-----GSQQQCDEEMYILEETTTGEEEHQ 130

  Fly   133 EDQSQEVLDFNGFIINESIEEDEEPNTESPEQILISHMDSYVDDQQMEELIDDKGELVEELSNAN 197
            |::..|          |.:|.|     .|.:|..|.....|::|....|:..|:.|:|.|
  Fly   131 EEKGHE----------EYLEVD-----TSDQQECIGDTIEYLEDNYTIEMNSDQTEIVLE----- 175

  Fly   198 TFYEVEYGDEELLMSSAPSPHPSFKMDKQKPGRPRKPDAELKFK----RKDINA------KERGN 252
              .|.:|  ||.         ||.::..|:..:     |.||.:    |:.:|:      .|:|.
  Fly   176 --SEKQY--EET---------PSQQLALQEAAK-----ASLKARRGRVRRGLNSLTTSDGTEKGG 222

  Fly   253 QPKCKEEEKFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRRHTGDRP 317
                     ::|.:|||.:.|:.....|...|.....:.||:|:..|:...:||.|:..|||.:|
  Fly   223 ---------YICDVCGNFYEKRGRMMEHRRRHDGICQYACELCDAKFQVREQLRKHMYSHTGSKP 278

  Fly   318 YKCMYCDRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCKS 382
            |||.:|.|.|:..|....||.||...:||.|:.|.|.|.:...|..|.|.||..|.|.|..|.|.
  Fly   279 YKCSFCSRQFFYESVLKSHENVHRGIKPYVCKVCDKAFAYAHSLTKHELIHSDIKLYRCDYCNKD 343

  Fly   383 FTLLHQLKAHLQTLTHRN 400
            |.|||.::.|.:|..|:|
  Fly   344 FRLLHHMRQHEETKLHQN 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	18/75 (24%)
		COG5048	<261..395	CDD:227381	50/133 (38%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-C2H2	290..312	CDD:278523	7/21 (33%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		zf-H2C2_2	304..327	CDD:290200	12/22 (55%)
		C2H2 Zn finger	320..340	CDD:275368	7/19 (37%)
		zf-H2C2_2	335..357	CDD:290200	10/21 (48%)
		C2H2 Zn finger	348..368	CDD:275368	7/19 (37%)
		C2H2 Zn finger	376..395	CDD:275368	8/18 (44%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	19/76 (25%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	46/112 (41%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..288	CDD:290200	12/21 (57%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	294..318	CDD:290200	10/23 (43%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C1GA
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860