DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14710 and CG11247

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	353	Identity:	81/353 - (22%)
Similarity:	127/353 - (35%)	Gaps:	114/353 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 IEEDEEPNTESPEQILISHMDSYVDDQQMEELIDDKGELVEELSNANTFYEVEYGDEELLMSSAP 215
            ::|:|:...|..     |..|.||..|..:..  .|||.|:...:..:....|:|.:..|..
  Fly    56 VDEEEDDGGEQD-----SKDDDYVQPQLKKSA--RKGEPVKRKHHVCSQCSKEFGGKTDLQR--- 110

  Fly   216 SPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKERGNQPKCKEEEKFMCILCGNVFYKKSVFTAH 280
              |.....|:    ||.|.....|..|:.:|.|....... :..::|:|..|...|..|.....|
  Fly   111 --HMLIHSDE----RPHKCKDCGKSYRQAVNLKNHITTAH-EHRKQFVCSQCPKSFALKERLRLH 168

  Fly   281 MMTHSEYKPHQCEICNKSFRQMGE----------------------------------------- 304
            |..||..||:.|::|:|.|.:.|:
  Fly   169 MRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQG 233

  Fly   305 -----------------LRAHI-----------------------------RRHTGDRPYKCMYC 323
                             |||||                             :|||..:.:.|..|
  Fly   234 MEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVC 298

  Fly   324 DRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHILSHSAQKNYNCGICCK--SFTLL 386
            :.:|..:|:...|.|:||..|||.|:.|.:||.|:::||.||..|:.:|.:.|.:|..  :|:.|
  Fly   299 NTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQL 363

  Fly   387 HQLKAHLQTLTHRNKMEQTIPSSPEMLE 414
            ..||.|::.:..:.|        |.|.|
  Fly   364 AHLKNHMKKIHKQQK--------PYMCE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071
		COG5048	<261..395	CDD:227381	53/222 (24%)
		C2H2 Zn finger	264..284	CDD:275368	6/19 (32%)
		zf-C2H2	290..312	CDD:278523	10/108 (9%)
		C2H2 Zn finger	292..312	CDD:275368	10/106 (9%)
		zf-H2C2_2	304..327	CDD:290200	10/109 (9%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..357	CDD:290200	11/21 (52%)
		C2H2 Zn finger	348..368	CDD:275368	9/19 (47%)
		C2H2 Zn finger	376..395	CDD:275368	7/20 (35%)
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	29/168 (17%)
		C2H2 Zn finger	95..115	CDD:275368	4/24 (17%)
		zf-H2C2_2	107..132	CDD:290200	7/33 (21%)
		C2H2 Zn finger	123..144	CDD:275368	4/20 (20%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	36/176 (20%)
		C2H2 Zn finger	210..230	CDD:275370	0/19 (0%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	0/19 (0%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840