DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14710 and CG30431

DIOPT Version :9

Sequence 1:	NP_650092.4	Gene:	CG14710 / 41393	FlyBaseID:	FBgn0037920	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_610211.1	Gene:	CG30431 / 35549	FlyBaseID:	FBgn0050431	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	415	Identity:	103/415 - (24%)
Similarity:	171/415 - (41%)	Gaps:	74/415 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LQCRICLGDFEESQMICLFGDKGESDLRKKLE-LCCRIRVRQSPQLPEKACNSCCEFVQMWFNFR 71
            |.||.||  .|:..:.....| ..|.|..:|: |...:|:.....|.:..|:.|...:....:|:
  Fly    10 LVCRCCL--LEQPPLYHSLYD-ASSQLAVELKALAPALRLEHGDNLTDVICDLCLRRLHDARDFQ 71

  Fly    72 QMCLNSQ-------VYWETSSSERPEALAQASDAEYMLYLYENLHLKLGTENQEKEEITAIEEGD 129
            :.|.:|:       .:|:.:.:. .:|||.....|.:.....:|...:....|..:.:..:.
  Fly    72 RRCEHSEQVLRMRHEHWKHTVAV-GDALALDDVLECLEREVGSLEGPMSVPLQASKPVAHVA--- 132

  Fly   130 EQQEDQSQEVLDFNGFIINESIEEDEEPNTESPEQILISHMDSYVDDQQMEELIDDKGELVEELS 194
                 ...|.:||      ||::..:..::|..   :.|:.:|.|          |.|.|
  Fly   133 -----PLMETVDF------ESLDFQDSSHSEHD---IPSYWESSV----------DSGSL----- 168

  Fly   195 NANT-FYEVEYGDEELLMSSAPSPHPS--------FKMDKQKPGRPRKPDAELKFKRKDINAKER 250
              || .::.|  ..||.....|:|..|        .:..|.:..|||:.:.:.| :||...|...
  Fly   169 --NTPHHQPE--TAELFAVEPPTPPESSEEPAPDAAEKPKMRRARPRQDNVKPK-ERKASGAVHP 228

  Fly   251 GNQPKCKE-EEKFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQMGELRAHIRR-HT 313
            .:...|.| |:||    ..|...|..:...|.|....|   |||.|.|:|.....||.|::. |:
  Fly   229 RSLHPCPECEKKF----TRNFQLKLHMTAVHGMGEMRY---QCEECRKNFASRHSLRYHVKSVHS 286

  Fly   314 GDRPYKCMYCDRHFYDRSERVRHERVHT---NTRPYACQECGKTFTHTAILKNHILSH--SAQKN 373
            .:||:.|.:|||.|..|::.:.|.|.||   ..|.:.||.|.|::...:.|:.|:.||  :.::.
  Fly   287 TERPFGCQHCDRRFILRTQLLSHLRTHTGEAKPRIFECQRCSKSWPTKSDLRTHMRSHNPNMERP 351

  Fly   374 YNCGICCKSFTLLHQLKAHLQTLTH 398
            :.|..|.|:|.....|.:||  |.|
  Fly   352 FKCDRCSKAFFTRGHLNSHL--LVH 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14710	NP_650092.4	zf-AD	9..83	CDD:285071	18/81 (22%)
		COG5048	<261..395	CDD:227381	45/139 (32%)
		C2H2 Zn finger	264..284	CDD:275368	4/19 (21%)
		zf-C2H2	290..312	CDD:278523	9/22 (41%)
		C2H2 Zn finger	292..312	CDD:275368	8/20 (40%)
		zf-H2C2_2	304..327	CDD:290200	10/23 (43%)
		C2H2 Zn finger	320..340	CDD:275368	8/19 (42%)
		zf-H2C2_2	335..357	CDD:290200	9/24 (38%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..395	CDD:275368	7/18 (39%)
CG30431	NP_610211.1	zf-AD	11..82	CDD:285071	17/73 (23%)
		C2H2 Zn finger	234..255	CDD:275368	7/24 (29%)
		C2H2 Zn finger	264..285	CDD:275368	8/20 (40%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		zf-C2H2_8	305..373	CDD:292531	20/69 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	354..374	CDD:275368	8/21 (38%)
		zf-H2C2_2	366..389	CDD:290200	5/11 (45%)
		C2H2 Zn finger	382..403	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930