DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14710 and ZNF621

DIOPT Version :9

Sequence 1:NP_650092.4 Gene:CG14710 / 41393 FlyBaseID:FBgn0037920 Length:415 Species:Drosophila melanogaster
Sequence 2:NP_001091884.1 Gene:ZNF621 / 285268 HGNCID:24787 Length:439 Species:Homo sapiens


Alignment Length:291 Identity:82/291 - (28%)
Similarity:118/291 - (40%) Gaps:65/291 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 PEQILISHM------------DSYV---DDQQMEELIDDKGELV-EELSNANTFYEVEYGDEELL 210
            |:..||||:            |:.:   ..|..|..|.::|.:: :|.|.....:.:..|.  ||
Human    56 PKPALISHLERGEAPWGPDPWDTEILRGISQGGESWIKNEGLVIKQEASEETELHRMPVGG--LL 118

  Fly   211 MSSAPSPHPSFKMDKQKPGRPRKPDAELKFKRKDINAKE------------------RGNQP-KC 256
            .:  .|.|..||....|......|:..|:...|....||                  .|.:| ||
Human   119 RN--VSQHFDFKRKALKQTFNLNPNLILRGGMKFYECKECGKIFRYNSKLIRHQMSHTGEKPFKC 181

  Fly   257 KE--------------------EEKFMCILCGNVFYKKSVFTAHMMTHSEYKPHQCEICNKSFRQ 301
            ||                    |..:.|..||......:..|.|...|:..||::|:.|.|:||:
Human   182 KECGKAFKSSYDCIVHEKNHIGEGPYECKECGKGLSSNTALTQHQRIHTGEKPYECKECGKAFRR 246

  Fly   302 MGELRAHIRRHTGDRPYKCMYCDRHFYDRSERVRHERVHTNTRPYACQECGKTFTHTAILKNHIL 366
            ......|.|.|||::.|||..|.:.|..||..:.|:|:||..:||.|:||||.||.......|..
Human   247 SAAYLQHQRLHTGEKLYKCKECWKAFGCRSLFIVHQRIHTGEKPYQCKECGKAFTQKIASIQHQR 311

  Fly   367 SHSAQKNYNCGICCKSFT-----LLHQLKAH 392
            .|:.:|.|.|.:|.|:|.     :.|| |.|
Human   312 VHTGEKPYECKVCGKAFKWYGSFVQHQ-KLH 341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14710NP_650092.4 zf-AD 9..83 CDD:285071
COG5048 <261..395 CDD:227381 50/137 (36%)
C2H2 Zn finger 264..284 CDD:275368 5/19 (26%)
zf-C2H2 290..312 CDD:278523 7/21 (33%)
C2H2 Zn finger 292..312 CDD:275368 7/19 (37%)
zf-H2C2_2 304..327 CDD:290200 9/22 (41%)
C2H2 Zn finger 320..340 CDD:275368 7/19 (37%)
zf-H2C2_2 335..357 CDD:290200 12/21 (57%)
C2H2 Zn finger 348..368 CDD:275368 8/19 (42%)
C2H2 Zn finger 376..395 CDD:275368 8/22 (36%)
ZNF621NP_001091884.1 KRAB 11..71 CDD:214630 5/14 (36%)
COG4049 145..198 CDD:226535 9/52 (17%)
C2H2 Zn finger 153..173 CDD:275368 2/19 (11%)
zf-H2C2_2 166..190 CDD:316026 6/23 (26%)
C2H2 Zn finger 209..229 CDD:275368 5/19 (26%)
zf-H2C2_2 221..246 CDD:316026 9/24 (38%)
C2H2 Zn finger 237..257 CDD:275368 7/19 (37%)
C2H2 Zn finger 265..285 CDD:275368 7/19 (37%)
zf-H2C2_2 281..302 CDD:316026 12/20 (60%)
C2H2 Zn finger 293..313 CDD:275368 8/19 (42%)
zf-H2C2_2 308..329 CDD:316026 7/20 (35%)
C2H2 Zn finger 321..341 CDD:275368 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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