DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and ZNF665

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	941	Identity:	181/941 - (19%)
Similarity:	279/941 - (29%)	Gaps:	406/941 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 MQRHSFPG-AGGRPRLGSGLSVRPTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWK-- 181
            :|:.:.|| ...|.|..:|          |...||      :|||.:           |.|..
Human   143 LQKENLPGRRAQRDRRAAG----------NRHIEN------QLGVSF-----------QSHLPEL 180

  Fly   182 ---RHMNHIHKYNTL------RGLNFTPLDKLYQRCRECNKRIAMHSRENLLKHKFTHL---PFR 234
               :|...|::||.:      ||.::        :|.||.|..:.:||  |..||..|.   |::
Human   181 QQFQHEGKIYEYNQVEKSPNNRGKHY--------KCDECGKVFSQNSR--LTSHKRIHTGEKPYQ 235

  Fly   235 CTKCYICKREYKYRQDLMVHLRMVH-------CDEVVAMMREGYNAAGRKTRVRESRTEQLLREK 292
            |.|   |.:.:..|.:|.:| :::|       |:|...:..:..|.||.: |:.
Human   236 CNK---CGKAFTVRSNLTIH-QVIHTGEKPYKCNECGKVFSQPSNLAGHQ-RIH----------- 284

  Fly   293 SFRENDDLGEESDRIEVRNELLEPDADESGTQEQTVSEEVSKKKAGTRGAAELCEDYIHYMCPDC 357
                   .||:.                                               |.|.:|
Human   285 -------TGEKP-----------------------------------------------YKCNEC 295

  Fly   358 GTDCDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEW 422
            |.....|::.:.| :.:|           :.:...:|.||.|..|.|:  .|.:|:..|..:..:
Human   296 GKAFRAHSKLTTH-QVIH-----------TGEKPYKCKECGKCFTQNS--HLASHRRIHTGEKPY 346

  Fly   423 LRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDE 487
             :|..|.|.::....:..|  |..|            .|:.|... :||          |.....
Human   347 -KCNECGKAFSVRSSLTTH--QTIH------------TGEKPYKC-NEC----------GKVFRH 385

  Fly   488 DSPYFEDAPRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINE 552
            :| |.  |..|  ||.:.:  :|   |.|.:|||.|           ..||  :|:|.......|
Human   386 NS-YL--AKHR--RIHTGE--KP---YKCNECGKAF-----------SMHS--NLTKHQIIHTGE 427

  Fly   553 RQLKCTECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRK 617
            :..||.||.|:.|....:.|   ||..|...|.| ||.:|.|:::.|..|..|.|.|
Human   428 KPFKCNECVKVFTQYSHLAN---HRRIHTGEKPY-RCDECGKAFSVRSSLTTHQAIH-------- 480

  Fly   618 LSGGCPAPILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPP 682
             :|..|
Human   481 -TGEKP----------------------------------------------------------- 485

  Fly   683 SPPPPPQPTTQGNHQRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSADPSVPTVE 747
                            |||..||.:|...:    |::..|           .:.|...|
Human   486 ----------------YKCNDCGKVFTQNS----HLASHR-----------GIHSGEKP------ 513

  Fly   748 QNYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQC-KDIVCNSKLKGLQ 811
                :.|..||..:....:..||. .||..:|            .|:|.:| |....:|.|...|
Human   514 ----YKCDECGKAFSQTSQLARHW-RVHTGEK------------PYKCNECGKAFSVHSSLTIHQ 561

  Fly   812 DHHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENP 876
            ..|....||    ||..||..:.|...:|.|.|    |...|.|            ||.|.
Human   562 TIHTGQKPY----KCNDCGKVFRHNSYLAIHQR----IHTGEKP------------YKCNE---- 602

  Fly   877 KLPSPPPAPALAPAPPSPPACSSSAAASASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVDLDF 941
                                |..:.                        ::..:::.|..:....
Human   603 --------------------CGKAF------------------------SVHSNLATHQVIHTGE 623

  Fly   942 ITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQL 1006
            ..|.|.:|.:.|..::    |:......::.|         ..|.|.||.|..:|..|      |
Human   624 KPYKCNECGKVFTQNS----HLANHRRIHTGE---------KPYRCNECGKAFSVRST------L 669

  Fly  1007 QSHKFRHLPHRSFKCLTCGGEFVRKQMFFKH 1037
            .:|...|...:.:||..||..|.:.....||
Human   670 TTHMAVHTGDKPYKCNQCGKVFTQNSNLAKH 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	3/25 (12%)
		C2H2 Zn finger	208..230	CDD:275368	9/21 (43%)
		C2H2 Zn finger	235..256	CDD:275368	6/20 (30%)
		C2H2 Zn finger	516..532	CDD:275368	5/15 (33%)
		C2H2 Zn finger	557..580	CDD:275368	8/22 (36%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		COG5236	<939..>1096	CDD:227561	23/99 (23%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	130/660 (20%)
		C2H2 Zn finger	208..228	CDD:275368	9/21 (43%)
		C2H2 Zn finger	236..256	CDD:275368	6/23 (26%)
		C2H2 Zn finger	264..284	CDD:275368	6/20 (30%)
		C2H2 Zn finger	292..312	CDD:275368	5/20 (25%)
		C2H2 Zn finger	320..340	CDD:275368	8/21 (38%)
		C2H2 Zn finger	348..368	CDD:275368	5/21 (24%)
		C2H2 Zn finger	376..396	CDD:275368	8/35 (23%)
		C2H2 Zn finger	404..424	CDD:275368	9/32 (28%)
		C2H2 Zn finger	432..452	CDD:275368	8/22 (36%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	6/34 (18%)
		C2H2 Zn finger	516..536	CDD:275368	5/20 (25%)
		C2H2 Zn finger	544..564	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	7/23 (30%)
		zf-H2C2_2	584..608	CDD:316026	10/87 (11%)
		C2H2 Zn finger	600..620	CDD:275368	3/67 (4%)
		zf-H2C2_2	612..637	CDD:316026	5/24 (21%)
		C2H2 Zn finger	628..648	CDD:275368	4/23 (17%)
		zf-H2C2_2	640..664	CDD:316026	7/32 (22%)
		C2H2 Zn finger	656..676	CDD:275368	8/25 (32%)
		zf-H2C2_2	669..693	CDD:316026	8/23 (35%)
		C2H2 Zn finger	684..704	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930