DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and ZNF142

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	1726	Identity:	297/1726 - (17%)
Similarity:	457/1726 - (26%)	Gaps:	820/1726 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 NMEPIVDIAE--------PQRPSLAPAGPMSQQVRP------PMQRHSFPGAGGRPRLGSGLSVR 141
            :::|:..::.        |..|:|  .||:..|..|      |:.|..|              .:
Human   127 HIQPVQGLSSPPCSVELPPSNPTL--PGPLQGQSPPVSPLSCPVCRQEF--------------AQ 175

  Fly   142 PTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQ 206
            |...:.:.....|.|..:.      ||..|..|..:|  ::.:.| |...|.|.:   |:...::
Human   176 PQALKSHFKIHRGTPDTFS------CPESGCVFSAED--RKGLQH-HLRQTHRAV---PVPCSFR 228

  Fly   207 RCRECNKRIAMHSRENLLKHKFTHLPFRCTKC-YICKREYKYRQDLMVHLRMVHCDEVVAMMREG 270
            .|     .:...|::.:..|:..|.||.|:.| :|......:||....|               |
Human   229 GC-----PLLFGSQQGMELHRQAHYPFHCSHCSFIGSNVKLFRQHQRSH---------------G 273

  Fly   271 YNAAGRKTRVRESRTEQLLREKSFRENDDLGEESDRIEVRNELLEPDADESGT----QEQTVSEE 331
            ....|..:.|:...:::||.......    ||.           || :.|:||    ||....|.
Human   274 AGTQGELSAVQGLPSQELLPAPKLPP----GER-----------EP-SQEAGTPLPGQETAEEEN 322

  Fly   332 VSK-KKAGT-----------RGAAELCEDYIH--------YMCPDCGTDC---DTHAQWSQHIEF 373
            |.| :|:.|           :||..|..|.:.        :|||:| ..|   .||.     :|.
Human   323 VEKEEKSDTQKDSQKAVDKGQGAQRLEGDVVSGTESLFKTHMCPEC-KRCFKKRTHL-----VEH 381

  Fly   374 VHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEI 438
            :|       |:|  .|..:||..|:|..|..:  .|:.|....|.:... .|.||:....:...:
Human   382 LH-------LHF--PDPSLQCPNCQKFFTSKS--KLKTHLLRELGEKAH-HCPLCHYSAVERNAL 434

  Fly   439 IRHLLQQH------HMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPL---DEDSPYFED 494
            .||:...|      :.||.......|| .....|:::..............||   .|...|  .
Human   435 NRHMASMHEDISNFYSDTYACPVCREE-FRLSQALKEHLKSHTAAAAAEPLPLRCFQEGCSY--A 496

  Fly   495 APRRGGRI-----------------SSDDIF----------EPHIDYLCPQ----CGKEFIEKKH 528
            ||.|...|                 |...:|          :.|..:.||.    |..:.:.:||
Human   497 APDRKAFIKHLKETHGVRAVECRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKH 561

  Fly   529 -------------------------WRTHVVMAHS---MNDLSKLNFEMINERQL---------- 555
                                     ::.||...|:   ::...:.||...::|.|
Human   562 KKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCPECNFATAHKRVLIRHMLLHTGE 626

  Fly   556 ---KCTECDKIITNAYGIQNAQQHRITHLPFKAYA---------------------------RCR 590
               ||..||   .....:....:|.:||...|.|.                           :|.
Human   627 KPHKCELCD---FTCRDVSYLSKHMLTHSNTKDYMCTECGYVTKWKHYLRVHMRKHAGDLRYQCN 688

  Fly   591 KC------------HKSYTDRKGLV---------------KHLATHHRVGWP------------- 615
            :|            ||.....|.|:               ||:|:.|..|.|
Human   689 QCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHPGTPAPLYPCHYCSYQS 753

  Fly   616 ---------------------------------------RKLSGGCP------------------ 623
                                                   ||..|..|
Human   754 RHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKRKAHGYVPGDQAWQLRYASQEPEGAM 818

  Fly   624 -APILTPAKQPRKQIV-----------TVANETYEI----------------------------- 647
             .|...|..:|..|:.           ||.:.:.:.
Human   819 QGPTPPPDSEPSNQLSARPEGPGHEPGTVVDPSLDQALPEMSEEVNTGRQEGSEAPHGGDLGGSP 883

  Fly   648 ------------------IYLDDVDQGGMEEDNDFG----------------------------E 666
                              :.|:.|.:..:||..:..                            .
Human   884 SPAEVEEGSCTLHLEALGVELESVTEPPLEEVTETAPMEFRPLGLEGPDGLEGPELSSFEGIGTS 948

  Fly   667 QMQAEED---EYPIAPP---PPS---------------PPP-----PPQPTT------------- 692
            .:.|||:   |.|::.|   |||               ||.     ||.|.:
Human   949 DLSAEENPLLEKPVSEPSTNPPSLEEAPNNWVGTFKTTPPAETAPLPPLPESESLLKALRRQDKE 1013

  Fly   693 ----------------QGNHQRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSADP 741
                            ||..:.::|.||..:...:.|:.:|      .:|..:.||:|:
Human  1014 QAEALVLEGRVQMVVIQGEGRAFRCPHCPFITRREKALNLH------SRTGCQGRREPL------ 1066

  Fly   742 SVPTVEQNYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSK 806
                       |||.||..:|.|
Human  1067 -----------LCPECGASFKQQ------------------------------------------ 1078

  Fly   807 LKGLQDHHFRHLPYRLY-------------LKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMI 858
             :||..|..:..|..|.             |:.::.||            :|.......:.|...
Human  1079 -RGLSTHLLKKCPVLLRKNKGLPRPDSPIPLQPVLPGT------------QASEDTESGKPPPAS 1130

  Fly   859 TKPKQVLGRYKDNSRENPKLP------------SP-PPA----PALAPA----PPSPPACSSSAA 902
            .:.:.:|.  ||...|.|:.|            || |||    |..||.    .|.|||.:||..
Human  1131 QEAELLLP--KDAPLELPREPEETEEPLATVSGSPVPPAGNSLPTEAPKKHCFDPVPPAGNSSPT 1193

  Fly   903 ASASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVDLDFITYFCPKCNQNFDSHAFWRKHIVE-- 965
            .:.....|.|.|      |||.::..:::..|......|....||.......|..   .|:.|
Human  1194 EAPKKHHLDPVP------PAGNSSPTEALKKHRFEQGKFHCNSCPFLCSRLSSIT---SHVAEGC 1249

  Fly   966 --QHNFNSREGLNFRQID---------------------------------NHHYLCLEC----- 990
              ......:.|....|.|                                 ...:.|..|
Human  1250 RGGRGGGGKRGTPQTQPDVSPLSNGDSAPPKNGSTESSSGDGDTVLVQKQKGARFSCPTCPFSCQ 1314

  Fly   991 YKRVTVTH--------------------TKGAIGQLQSH-KFRH---------LPHRSFKCLTCG 1025
            .:|...||                    |..|...|:.| |.||         .||  .:|..||
Human  1315 QERALRTHQIRGCPLEESGELHCSLCPFTAPAATALRLHQKRRHPTAAPARGPRPH--LQCGDCG 1377

  Fly  1026 GEFVRKQMFFKHLNRDTNRCDNRPHREFDDD--EPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWR 1088
              |..||          :|| .:.||....:  :|.|           ||.|  :|.|..:....
Human  1378 --FTCKQ----------SRC-MQQHRRLKHEGVKPHQ-----------CPFC--DFSTTRRYRLE 1416

  Fly  1089 EHINDHHGLTKLELLHMTKVGEDVYRCQDCDEELETNRQWVLQFHRFQ-------HL----PHAA 1142
            .|.:.|.|:.::.             |..|.:...||.:  |:.||.:       |.    .::.
Human  1417 AHQSRHTGIGRIP-------------CSSCPQTFGTNSK--LRLHRLRVHDKTPTHFCPLCDYSG 1466

  Fly  1143 YIR------------------CKLC----------KQSS----------ADGADA---VGELHSL 1166
            |:|                  |..|          ||.:          |.|:.|   .|.||..
Human  1467 YLRHDITRHVNSCHQGTPAFACSQCEAQFSSETALKQHALRRHPEPAQPAPGSPAETTEGPLHCS 1531

  Fly  1167 R---------ELQQHIRKHHPGL---------------------------------GDAEMISLI 1189
            |         .|:.|.||.||.|                                 ...|.:.|:
Human  1532 RCGLLCPSPASLRGHTRKQHPRLECGACQEAFPSRLALDEHRRQQHFSHRCQLCDFAARERVGLV 1596

  Fly  1190 EQIIQDEKEQEEGTEQTNDGENPTGQDSGPYMPLPP 1225
            :..: ::.|:.......:||:...||        ||
Human  1597 KHYL-EQHEETSAAVAASDGDGDAGQ--------PP 1623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	6/20 (30%)
		C2H2 Zn finger	208..230	CDD:275368	3/21 (14%)
		C2H2 Zn finger	235..256	CDD:275368	6/21 (29%)
		C2H2 Zn finger	516..532	CDD:275368	5/44 (11%)
		C2H2 Zn finger	557..580	CDD:275368	4/22 (18%)
		C2H2 Zn finger	589..609	CDD:275368	9/46 (20%)
		COG5236	<939..>1096	CDD:227561	42/230 (18%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368	8/32 (25%)
		C2H2 Zn finger	393..413	CDD:275368	6/21 (29%)
		C2H2 Zn finger	421..438	CDD:275368	4/16 (25%)
		C2H2 Zn finger	455..475	CDD:275368	3/20 (15%)
		C2H2 Zn finger	545..566	CDD:275368	5/20 (25%)
		C2H2 Zn finger	574..595	CDD:275368	2/20 (10%)
		zf-H2C2_5	601..625	CDD:404746	4/23 (17%)
		C2H2 Zn finger	603..623	CDD:275368	4/19 (21%)
		C2H2 Zn finger	631..651	CDD:275368	4/22 (18%)
		C2H2 Zn finger	659..679	CDD:275368	0/19 (0%)
		C2H2 Zn finger	687..707	CDD:275368	4/19 (21%)
		C2H2 Zn finger	714..731	CDD:275368	1/16 (6%)
		PHA03247	928..>1219	CDD:223021	68/376 (18%)
		C2H2 Zn finger	1306..1353	CDD:275368	8/46 (17%)
		C2H2 Zn finger	1373..1394	CDD:275368	10/33 (30%)
		C2H2 Zn finger	1402..1422	CDD:275368	6/21 (29%)
		C2H2 Zn finger	1430..1451	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100