DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and ZNF91

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_003421.2	Gene:	ZNF91 / 7644	HGNCID:	13166	Length:	1191	Species:	Homo sapiens

Alignment Length:	1126	Identity:	231/1126 - (20%)
Similarity:	360/1126 - (31%)	Gaps:	360/1126 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 YICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQRCRECNKRIAMHSRENLLKHKFT 229
            |.|..||..|:|......|.....|            :|:| :|.||.|.....|  .|.:||..
Human   238 YKCEECGKAFKQLSTLTTHKIICAK------------EKIY-KCEECGKAFLWSS--TLTRHKRI 287

  Fly   230 HLPFRCTKCYICKREYKYRQDLMVHLRMVH-------CDEVVAMMREGYNAAGRKTRVRESRTEQ 287
            |...:..||..|.:.:.:...|..|.| :|       |:|...........|..| |:.......
Human   288 HTGEKPYKCEECGKAFSHSSTLAKHKR-IHTGEKPYKCEECGKAFSRSSTLAKHK-RIHTGEKPY 350

  Fly   288 LLRE--KSFRENDDLGEESDRIEVRNELLEPDADESGTQEQTVSEEVSKK-----KAGTRGAAEL 345
            ..:|  |:|..:..|                     ...:.|.:||...|     ||..|.:...
Human   351 KCKECGKAFSNSSTL---------------------ANHKITHTEEKPYKCKECDKAFKRLSTLT 394

  Fly   346 CEDYIH-----YMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNT 405
            ....||     |.|.:||...:..:..:.| :|:|           :.:...:|.||.|..  |.
Human   395 KHKIIHAGEKLYKCEECGKAFNRSSNLTIH-KFIH-----------TGEKPYKCEECGKAF--NW 445

  Fly   406 IKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDE 470
            ..||..||..|..:..: :||.|.|.:.....:.||  ::.|            .|:.|...| |
Human   446 SSSLTKHKRFHTREKPF-KCKECGKAFIWSSTLTRH--KRIH------------TGEKPYKCE-E 494

  Fly   471 CDGDNGNGEGNGAPLDE-------DSPY-FED---APRRGGRISSDDIF----EPHIDYLCPQCG 520
            |    |......:.|.:       :.|| ||:   |.|:...::...|.    :|   |.|.:||
Human   495 C----GKAFRQSSTLTKHKIIHTGEKPYKFEECGKAFRQSLTLNKHKIIHSREKP---YKCKECG 552

  Fly   521 KEFIEKKHWRTHVVM------------AHSMNDLSKLNFEMI---NERQLKCTECDKIITNAYGI 570
            |.|.:.....||.::            ..:.|..|.|:...|   .|:..||.||.|....:
Human   553 KAFKQFSTLTTHKIIHAGKKLYKCEECGKAFNHSSSLSTHKIIHTGEKSYKCEECGKAFLWS--- 614

  Fly   571 QNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPAPILTPAKQPRK 635
            ...::|:..|...|.| :|.:|.|:::....|.||...|                   ..::|.|
Human   615 STLRRHKRIHTGEKPY-KCEECGKAFSHSSALAKHKRIH-------------------TGEKPYK 659

  Fly   636 ---------QIVTVANETYEIIYLDDVDQGGMEEDNDF--------------GEQMQAEED---- 673
                     ...|:||  ::|.:.::......|.|..|              ||::...|:
Human   660 CKECGKAFSNSSTLAN--HKITHTEEKPYKCKECDKTFKRLSTLTKHKIIHAGEKLYKCEECGKA 722

  Fly   674 ----------------EYPIAPPPPSPPPPPQPTTQGNHQRYKCVHCGTLFATQAAV----RVHI 718
                            |.|                      |||..||..|...:::    |:|.
Human   723 FNRSSNLTIHKFIHTGEKP----------------------YKCEECGKAFNWSSSLTKHKRIHT 765

  Fly   719 SEK--RCRK---------TVVRRRRQPVMSSADPSVPTVEQNYIFLCPSCGFEYKTQFEWRRHIN 772
            .||  :|::         |:.|.:|          :.|.|:.|  .|..||..:.......:| .
Human   766 REKPFKCKECGKAFIWSSTLTRHKR----------IHTGEKPY--KCEECGKAFSRSSTLTKH-K 817

  Fly   773 EVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLICGTCYNHKP 837
            .:|..:|            .|:|.:|.....:|  ..|..|...|...:|| ||..||..:|...
Human   818 TIHTGEK------------PYKCKECGKAFKHS--SALAKHKIIHAGEKLY-KCEECGKAFNQSS 867

  Fly   838 NIAAHLRARHSIFDRETP-------------TMITKPKQVLGRYKDNSRENP----KLPSPPPAP 885
            |:..|    ..|..:|.|             :.:|:.|::..|.|....|..    ..||.....
Human   868 NLTTH----KIIHTKEKPSKSEECDKAFIWSSTLTEHKRIHTREKTYKCEECGKAFSQPSHLTTH 928

  Fly   886 ALAPAPPSPPACSSSAAASASSRSL----------KP---QPGGLPARPAGLNTLEDSISYHNAV 937
            ........|..|.....|.:.|.:|          ||   :..|...|.:      .:::.|..:
Human   929 KRMHTGEKPYKCEECGKAFSQSSTLTTHKIIHTGEKPYKCEECGKAFRKS------STLTEHKII 987

  Fly   938 DLDFITYFCPKCNQNFDSHAFWRKHIVEQHN-------------FNSREGLNFRQI---DNHHYL 986
            ......|.|.:|.:.|...:...:| ...|.             ||....|...:|   ....|.
Human   988 HTGEKPYKCEECGKAFSQSSTLTRH-TRMHTGEKPYKCEECGKAFNRSSKLTTHKIIHTGEKPYK 1051

  Fly   987 CLECYKRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDTNRCDNRPHR 1051
            |.||.|....:.|      |..||..|...:.:||..||..|.:.....:|....|.   .:|::
Human  1052 CEECGKAFISSST------LNGHKRIHTREKPYKCEECGKAFSQSSTLTRHKRLHTG---EKPYK 1107

  Fly  1052 EFDDDEPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWREHINDHHGLTKLELLHMTKVGEDVYRCQ 1116
                                |.:||..||            :...|||.:::|   .||..|:|:
Human  1108 --------------------CGECGKAFK------------ESSALTKHKIIH---TGEKPYKCE 1137

  Fly  1117 DCDEELETNRQWVLQFHRFQH 1137
            .|.:..  |:..:|..|:..|
Human  1138 KCGKAF--NQSSILTNHKKIH 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	6/20 (30%)
		C2H2 Zn finger	208..230	CDD:275368	8/21 (38%)
		C2H2 Zn finger	235..256	CDD:275368	5/20 (25%)
		C2H2 Zn finger	516..532	CDD:275368	5/15 (33%)
		C2H2 Zn finger	557..580	CDD:275368	5/22 (23%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		COG5236	<939..>1096	CDD:227561	33/172 (19%)
ZNF91	NP_003421.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	155..176	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368
		COG5048	<220..370	CDD:227381	35/169 (21%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		C2H2 Zn finger	268..288	CDD:275368	8/21 (38%)
		zf-H2C2_2	281..305	CDD:290200	7/23 (30%)
		C2H2 Zn finger	296..316	CDD:275368	5/20 (25%)
		zf-H2C2_2	309..333	CDD:290200	6/24 (25%)
		COG5048	320..708	CDD:227381	95/471 (20%)
		C2H2 Zn finger	324..344	CDD:275368	5/20 (25%)
		zf-H2C2_2	337..361	CDD:290200	6/24 (25%)
		C2H2 Zn finger	352..372	CDD:275368	4/40 (10%)
		zf-H2C2_2	365..389	CDD:290200	7/44 (16%)
		C2H2 Zn finger	380..400	CDD:275368	3/19 (16%)
		C2H2 Zn finger	408..428	CDD:275368	5/20 (25%)
		C2H2 Zn finger	436..456	CDD:275368	9/21 (43%)
		zf-H2C2_2	448..471	CDD:290200	9/23 (39%)
		C2H2 Zn finger	464..484	CDD:275368	6/21 (29%)
		zf-H2C2_2	477..501	CDD:290200	9/42 (21%)
		C2H2 Zn finger	492..512	CDD:275368	5/24 (21%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		zf-H2C2_2	533..557	CDD:290200	8/26 (31%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	4/19 (21%)
		C2H2 Zn finger	604..624	CDD:275368	5/22 (23%)
		zf-H2C2_2	617..641	CDD:290200	7/24 (29%)
		COG5048	628..1069	CDD:227381	99/529 (19%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		zf-H2C2_2	644..669	CDD:290200	6/43 (14%)
		C2H2 Zn finger	660..680	CDD:275368	4/21 (19%)
		C2H2 Zn finger	688..708	CDD:275368	3/19 (16%)
		C2H2 Zn finger	716..736	CDD:275368	1/19 (5%)
		C2H2 Zn finger	744..764	CDD:275368	5/19 (26%)
		zf-H2C2_2	756..779	CDD:290200	5/22 (23%)
		C2H2 Zn finger	772..792	CDD:275368	4/29 (14%)
		zf-H2C2_2	785..809	CDD:290200	8/35 (23%)
		C2H2 Zn finger	800..820	CDD:275368	4/20 (20%)
		zf-H2C2_2	813..837	CDD:290200	6/36 (17%)
		C2H2 Zn finger	828..848	CDD:275368	5/21 (24%)
		C2H2 Zn finger	856..876	CDD:275368	6/23 (26%)
		C2H2 Zn finger	885..904	CDD:275368	2/18 (11%)
		C2H2 Zn finger	912..932	CDD:275368	3/19 (16%)
		zf-H2C2_2	924..949	CDD:290200	3/24 (13%)
		C2H2 Zn finger	940..960	CDD:275368	4/19 (21%)
		C2H2 Zn finger	968..988	CDD:275368	3/25 (12%)
		zf-H2C2_2	981..1005	CDD:290200	5/23 (22%)
		C2H2 Zn finger	996..1016	CDD:275368	4/20 (20%)
		zf-H2C2_2	1009..1033	CDD:290200	3/24 (13%)
		C2H2 Zn finger	1024..1044	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1052..1072	CDD:275368	8/25 (32%)
		C2H2 Zn finger	1080..1100	CDD:275368	5/19 (26%)
		zf-H2C2_2	1093..1116	CDD:290200	6/45 (13%)
		C2H2 Zn finger	1108..1128	CDD:275368	8/31 (26%)
		zf-H2C2_2	1120..1145	CDD:290200	9/29 (31%)
		C2H2 Zn finger	1136..1156	CDD:275368	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910