DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6791 and ZNF84

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	759	Identity:	155/759 - (20%)
Similarity:	246/759 - (32%)	Gaps:	226/759 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 GTRGAAELCED-------YIHYMCPDCGT-----DCDTHAQWSQHIEFVHDYVSRRGLNFRSVDM 390
            |..|.|| .:|       ::|....|..|     |||.:.:..:..:.:..:.:|.|      :.
Human   148 GDYGKAE-SDDFNVFDNFFLHSKPEDTDTWLKYYDCDKYKESYKKSQIIIYHRNRLG------EK 205

  Fly   391 QMQCLECKKIVT--PNTIKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMS 453
            ..:|.||:|..:  |:.||    |:..|:....: .|..|.|.:....:.|.|    |...|
Human   206 LYECSECRKRFSKKPSLIK----HQSRHIRDIAF-GCGNCGKTFPQKSQFITH----HRTHT--- 258

  Fly   454 EDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDEDSPYFEDAPRRGGRISSDDIFEPHIDYLCPQ 518
                   |:.|... .:|          |....:.|..........|.       :|   |.|.:
Human   259 -------GEKPYNC-SQC----------GKAFSQKSQLTSHQRTHTGE-------KP---YECGE 295

  Fly   519 CGKEFIEK----KHWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQNAQQHRIT 579
            |||.|..|    .|||||.                 .|:...|.||.:..:....:.|.|:....
Human   296 CGKAFSRKSHLISHWRTHT-----------------GEKPYGCNECGRAFSEKSNLINHQRIHTG 343

  Fly   580 HLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSG--GCPAPILTPAKQPRKQIVTVAN 642
            ..||:    ||:|.|:::.:..||    ||||.....|..|  .|.......::..|.|.:....
Human   344 EKPFE----CRECGKAFSRKSQLV----THHRTHTGTKPFGCSDCRKAFFEKSELIRHQTIHTGE 400

  Fly   643 ETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQGNHQR-------YK 700
            :.||.                 .|..:|..:...:.                ||||       :.
Human   401 KPYEC-----------------SECRKAFRERSSLI----------------NHQRTHTGEKPHG 432

  Fly   701 CVHCGTLFATQAAV----RVHISEK-----RCRKTVVRR----RRQPVMSSADPSVPTVEQNYIF 752
            |:.||..|:.::.:    ..|..||     :|.|...|:    |.|...:...|          :
Human   433 CIQCGKAFSQKSHLISHQMTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTGEKP----------Y 487

  Fly   753 LCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVC-NSKLKGLQDHHFR 816
            .|..||..:..:.....| ..:|..:|            .|.|::|....| .|.|...|..|..
Human   488 ECSECGKAFSEKLSLTNH-QRIHTGEK------------PYVCSECGKAFCQKSHLISHQRTHTG 539

  Fly   817 HLPYRLYLKCLICGTCYNHKPNIAAHLRAR--HSIFD-RETPTMITKPKQVLGRYKDNSRENPKL 878
            ..||    :|..||..:..|.::|.|.|..  ...:: |:.....::..|:....:.::.|.|.
Human   540 EKPY----ECSECGKAFGEKSSLATHQRTHTGEKPYECRDCEKAFSQKSQLNTHQRIHTGEKPY- 599

  Fly   879 PSPPPAPALAPAPPSPPACSSSAAA----SASSRSLKPQPGGLP-----ARPAGLNTLEDSISYH 934
                             .||....|    |...|.|:...|..|     .|.|...  :.|:..|
Human   600 -----------------ECSLCRKAFFEKSELIRHLRTHTGEKPYECNECRKAFRE--KSSLINH 645

  Fly   935 NAVDLDFITYFCPKCNQNFDSHAFWRK-HIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTH 998
            ..:......:.|.:|.:     ||.|| |::.....::.|         ..|.|.||.|..:..
Human   646 QRIHTGEKPFECSECGK-----AFSRKSHLIPHQRTHTGE---------KPYGCSECRKAFSQK- 695

  Fly   999 TKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDT 1042
                 .||.:|:..|...:.::|:.||..|.:|.....|....|
Human   696 -----SQLVNHQRIHTGEKPYRCIECGKAFSQKSQLINHQRTHT 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368	9/19 (47%)
		C2H2 Zn finger	557..580	CDD:275368	5/22 (23%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		COG5236	<939..>1096	CDD:227561	24/105 (23%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368	8/23 (35%)
		C2H2 Zn finger	237..257	CDD:275368	6/23 (26%)
		C2H2 Zn finger	265..285	CDD:275368	3/30 (10%)
		zf-H2C2_2	278..302	CDD:316026	8/33 (24%)
		C2H2 Zn finger	293..313	CDD:275368	9/19 (47%)
		COG5048	317..724	CDD:227381	103/514 (20%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		C2H2 Zn finger	349..369	CDD:275368	10/23 (43%)
		C2H2 Zn finger	377..397	CDD:275368	3/19 (16%)
		C2H2 Zn finger	405..425	CDD:275368	6/52 (12%)
		C2H2 Zn finger	433..453	CDD:275368	4/19 (21%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	4/20 (20%)
		C2H2 Zn finger	517..537	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	2/19 (11%)
		C2H2 Zn finger	601..621	CDD:275368	6/19 (32%)
		C2H2 Zn finger	629..649	CDD:275368	4/21 (19%)
		C2H2 Zn finger	657..677	CDD:275368	7/24 (29%)
		C2H2 Zn finger	685..705	CDD:275368	7/25 (28%)
		C2H2 Zn finger	713..733	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910