DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and dati

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster

Alignment Length:	1275	Identity:	225/1275 - (17%)
Similarity:	354/1275 - (27%)	Gaps:	468/1275 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EAESGVAELEDSEQYGNGNDDFLGD-------------------TAILDSGDAIDDLLDAEEDER 64
            :|||.....:.|||...|:|.|.|.                   .|:.....|:.:.|....|:.
  Fly   137 KAESSHIPQQHSEQQSYGSDSFRGTQSPQLSSHHLLFNAAAAAAAAVHLKSTAMQNNLSPIGDQV 201

  Fly    65 EE----------------EDDYEKNSKEPKQPDPDDDALFDFNMEPIV-------------DIAE 100
            :.                :...|.::|.|.||       .|....|:|             |:|:
  Fly   202 QNNLRNYGQGSLNALCGIKPKQEMDAKTPLQP-------LDECPHPLVQAQAQSQYGGDYYDVAD 259

  Fly   101 PQRPSL-----------APAGPMSQQVRPPMQRHSFPGAG----------------GRPRLGSGL 138
            ||...:           ||:...:...:.....|...|.|                |...||:|.
  Fly   260 PQAREISEGRALIIGLGAPSTVSTDDAQSSAPSHQLAGTGRALQTHQCKPMSPGTVGSSNLGAGR 324

  Fly   139 SVRPTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPL-- 201
            ...|||  |:.|...|     :....:.....||.....          .|||..:..|...|
  Fly   325 RSAPTT--ISKTFSQG-----QQSPQHSTTPSGGSTTPD----------IKYNNDKMANEIQLQL 372

  Fly   202 ----------DKLYQRCRECNKRIAMHS-----------RENLLKHKFTH--------LPFRCTK 237
                      ::..:.|....:|:.||.           |..|..|..|.        .|...||
  Fly   373 SRSSSAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRVGLGTHGVTGSANLGGSITPSSDTK 437

  Fly   238 ---CYICKREYKYRQDLMVHLRMVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDD 299
               |..|.:.:.....|:.|:| ||..|      :.|     |....:.|.:||
  Fly   438 PHQCQQCMKSFSSNHQLVQHIR-VHTGE------KPY-----KCSYCDRRFKQL----------- 479

  Fly   300 LGEESDRIEVRNELLEPDADESGTQEQTVSEEVSKKKAGTRGAAELCEDYIHYMC--PDCGTDCD 362
                                 |..|:.|      :...|.|          .|.|  ||||....
  Fly   480 ---------------------SHVQQHT------RLHTGER----------PYKCHLPDCGRAFI 507

  Fly   363 THAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHL---------- 417
            ..:...||:. .||....|..|     ....|..|.|...  |..|||.|....|
  Fly   508 QLSNLQQHLR-NHDAQVERAKN-----RPFHCNICGKGFA--TESSLRTHTSKELQLHLGVLQQH 564

  Fly   418 ----SQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNG 478
                ..|....|.:|:|.:...:.::.|:...|      .|.:....|.|.|...:......|||
  Fly   565 AALIGGPNATSCPVCHKLFLGTEALVDHMKHVH------KEKSPPPGGSASSQFSELNQIVTGNG 623

  Fly   479 EGNGAPLDEDSPYFEDAPRRGGRISSDDIFEPHI------DYLCPQCGKEFIEKKHWRTHVVMAH 537
            .|.|:..::.:.................:.:..:      ::.||.|||.::.:...|.|:. .|
  Fly   624 NGTGSSNEQIATQCTTESNSHQATVGSSLIDSFLGKRRTANHPCPVCGKHYVNEGSLRKHLA-CH 687

  Fly   538 SMNDLSKLNFEMINE-RQLKCTECDKIITNAYGIQNAQQHRITHL---------PFKAYARCRKC 592
            :.|.      ::.|. |...|:.|..:.|:..|:       :||:         .|.|.....:.
  Fly   688 AENS------QLTNSLRMWPCSVCQAVFTHENGL-------LTHMESMRMDPKHQFAAQYVLSRA 739

  Fly   593 HKSYTDRKGL----------------------VKHLATHHRVGWPRKLSGGCPAPILTP--AKQP 633
            .....:|:.|                      |.....|:..|...|    ||:|....  :...
  Fly   740 AAEQRERESLLAVTLAASSGASTRIGIADAGNVLPTGAHNSDGSNSK----CPSPSANSECSSNG 800

  Fly   634 RKQIVTVANETYEIIYLDDVDQGGMEED----NDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQG 694
            |....|.:::.      .|:|.|..|.:    |:.|.......:                .|:..
  Fly   801 RLSSSTTSDQD------QDIDHGLSENENSNQNNIGSSTNNNNN----------------CTSNN 843

  Fly   695 NHQRYKCVHC---GTLFATQAAVRVHISEK------RCRKTVVRRRRQPVMSSADPSVPTVEQNY 750
            |...:|....   ||...|..| .:|::.:      ........|.:..|.:||.||. .|:...
  Fly   844 NASSHKMAELRLPGTGQYTMDA-ELHVANRMSLMAAAAAAVAASRPQDGVDTSAVPSA-AVQAAV 906

  Fly   751 IFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKG---LQD 812
            :.|..:                            ||.                |:...|   .|.
  Fly   907 VNLAAA----------------------------MRM----------------NNSSNGATPYQQ 927

  Fly   813 HHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENPK 877
            ||..|              ...|:.:|..|....|. ..::.|....:....|..:...|..|.:
  Fly   928 HHADH--------------TQAHQTHILQHAHPHHH-QQQQAPQHQQQQLSHLLVHTHPSNSNSR 977

  Fly   878 LPSPP--PAPALAPAPPSPPACSSSAAASASSR--------SLKPQP--GGLPARPAGLNTL--- 927
            ..|.|  ..|:|.         :.|.|||.:..        ||.|.|  ||:    .|:..|
  Fly   978 SQSSPNINVPSLQ---------NESTAASIAMNMNVHMMRGSLDPDPSLGGM----HGIEVLHQH 1029

  Fly   928 -EDSISYHNAVDLDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLECY 991
             :....:|:....::..:.....||:  :|...:.|....|:.:....|...|.:
  Fly  1030 QQQHHHHHHHHTSNYPQHAVTPTNQH--THPHPQTHQTAHHHTSPETALRMHQAE---------- 1082

  Fly   992 KRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDTN-RCDNRPHREFDD 1055
             .:..:||:.|                |:..|..|.             ||. :|
  Fly  1083 -AILRSHTEAA----------------FRLATGSGP-------------DTGVKC---------- 1107

  Fly  1056 DEPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWREHINDHH 1095
             |.||:.|.|.    .....|.| ...|.::.|.|.:.:|
  Fly  1108 -EADQNQLNSN----NAGNAGGN-SGGNSQQHRFHASSNH 1141

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	2/20 (10%)
		C2H2 Zn finger	208..230	CDD:275368	7/32 (22%)
		C2H2 Zn finger	235..256	CDD:275368	6/23 (26%)
		C2H2 Zn finger	516..532	CDD:275368	6/15 (40%)
		C2H2 Zn finger	557..580	CDD:275368	4/22 (18%)
		C2H2 Zn finger	589..609	CDD:275368	3/41 (7%)
		COG5236	<939..>1096	CDD:227561	27/158 (17%)
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	27/141 (19%)
		C2H2 Zn finger	441..461	CDD:275368	5/20 (25%)
		zf-H2C2_2	454..478	CDD:290200	9/35 (26%)
		C2H2 Zn finger	469..489	CDD:275368	6/57 (11%)
		zf-H2C2_2	481..508	CDD:290200	10/42 (24%)
		C2H2 Zn finger	497..519	CDD:275368	7/22 (32%)
		C2H2 Zn finger	533..557	CDD:275368	9/25 (36%)
		C2H2 Zn finger	576..594	CDD:275368	4/17 (24%)
		C2H2 Zn finger	667..687	CDD:275370	7/20 (35%)
		C2H2 Zn finger	702..719	CDD:275370	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100