DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG3281

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_650132.1	Gene:	CG3281 / 41445	FlyBaseID:	FBgn0260741	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	122/703 - (17%)
Similarity:	194/703 - (27%)	Gaps:	330/703 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSDFEEGEAESGVAELEDSEQYGNGNDDFLGDTAILDSGDAIDDLLDAEEDEREEEDDYEKNSKE 76
            |:.|.|       ..:|..|:||:      .|.:...|....:.|..:|:.:.|.||.::
  Fly   126 STSFAE-------QHVEMEEKYGD------QDCSAFTSDVGEEPLYASEDRDDEPEDSFQ----- 172

  Fly    77 PKQPDPDDDALFDFNMEPIVDIAEPQRPSLAPAGPMSQQVRPPMQRHSFPGAGGRPRLGSGLSVR 141
             .:|.||:           ::..|..|||                           :|||.|
  Fly   173 -LKPRPDE-----------IENRELSRPS---------------------------QLGSRL--- 195

  Fly   142 PTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQ 206
                            |:....:|.|..|...|.:.:...||.:..||...    :...:....:
  Fly   196 ----------------NHSANFIYKCAVCPRVFAKSESLTRHFSQAHKLTA----DVAAMKLANE 240

  Fly   207 RCRECNKRIAMHSRENLLKHKFTHLPFRCTKCYICKREYKYRQDLMVHLRMVHCDEVVAMMREGY 271
            .|           ...||            .|..|.|.:|.:..|..|::..|.|.:.
  Fly   241 SC-----------GTGLL------------TCEHCPRTFKRQDTLRRHMQAFHPDAIA------- 275

  Fly   272 NAAGRKTRVRESRTEQLLREKSFRENDDLGEESDRIEVRNELLEPDADESGTQEQTVSEEVSKKK 336
                                                      |||        |:|......|:.
  Fly   276 ------------------------------------------LEP--------EETTDNSARKRI 290

  Fly   337 AGTRGAAELCEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIV 401
            |..|.            ||.||..... :..:.||        ||    .:.|...:|.:|:| .
  Fly   291 AKRRD------------CPHCGLSFPV-SSLTIHI--------RR----HTGDNPYKCDQCEK-A 329

  Fly   402 TPNTIKSLRAHKFSHLSQ-PEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPS 465
            .|.: :.|..|...|..: |.  .||:|.|.:....::.|| ::.|             .|..|.
  Fly   330 FPRS-QDLSLHMRQHTGERPS--ECKICSKKFISQNKLARH-MRLH-------------TGQRPY 377

  Fly   466 AIEDECDGDNGNGEGNGAPLDEDSPYFEDAPRRGGRISSDDIFEPHI-------DYLCPQCGKEF 523
            :.: .|                 |..|         :.|:|: :.|:       .|.|..||:.|
  Fly   378 SCK-MC-----------------SKSF---------VQSNDL-KIHMRRHTGERPYQCGVCGESF 414

  Fly   524 IEKKHWRTH---------VVMAHSM-------------------NDLSKLNFEMINERQLKCTEC 560
            :...|...|         |:..:.:                   .|:.::..:.|.|.||
  Fly   415 VCGSHLNIHRNRKGHLIAVIPGNEVEANFAADPYVNARVNQRRSEDIERMRLQRIPENQL----- 474

  Fly   561 DKIITNAYGIQNAQQHRITHLPF-KAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPA 624
                          |.|:.:||. ...|.|.||  ...::|.....|.|.||    .|:|
  Fly   475 --------------QQRLENLPKPDVPAMCYKC--GVCEQKFKSGALLTVHR----NKMS----- 514

  Fly   625 PILTPAKQPRKQIVTVANETYEI--IYLDDVDQGGMEEDNDFGEQMQAEEDEY 675
                               .|||  :|           :|.||:..:..:.||
  Fly   515 -------------------HYEIERVY-----------ENPFGKNQKIIKAEY 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	5/20 (25%)
		C2H2 Zn finger	208..230	CDD:275368	3/21 (14%)
		C2H2 Zn finger	235..256	CDD:275368	6/20 (30%)
		C2H2 Zn finger	516..532	CDD:275368	5/15 (33%)
		C2H2 Zn finger	557..580	CDD:275368	2/22 (9%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		COG5236	<939..>1096	CDD:227561
CG3281	NP_650132.1	zf-AD	14..92	CDD:285071
		C2H2 Zn finger	205..226	CDD:275368	5/20 (25%)
		C2H2 Zn finger	249..266	CDD:275368	5/16 (31%)
		COG5048	<294..>391	CDD:227381	31/166 (19%)
		C2H2 Zn finger	296..315	CDD:275368	8/31 (26%)
		zf-H2C2_2	307..330	CDD:290200	8/35 (23%)
		C2H2 Zn finger	323..343	CDD:275368	6/21 (29%)
		zf-H2C2_2	335..358	CDD:290200	8/24 (33%)
		C2H2 Zn finger	351..371	CDD:275368	6/20 (30%)
		zf-H2C2_2	364..388	CDD:290200	8/64 (13%)
		C2H2 Zn finger	379..399	CDD:275368	6/47 (13%)
		zf-H2C2_2	391..416	CDD:290200	7/25 (28%)
		C2H2 Zn finger	407..424	CDD:275368	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100