DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG2199

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster

Alignment Length:	866	Identity:	153/866 - (17%)
Similarity:	260/866 - (30%)	Gaps:	344/866 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 NTLRGLNFTPLDKLYQRCREC----NKRIAMHSRENLLKHKFT-------------HLPFRCTKC 238
            |.|...|.|.:.| ..||..|    ..:.....::..|..|.|             .||.:.  |
  Fly     3 NILLCENMTKVQK-EVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITHRSIPSSLPIKI--C 64

  Fly   239 YICKREYKYRQDLMVHLRMVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDLGEE 303
            ::|...:.....|:..:|     |.|..::|   ...:||:|.|      :.|.|.:|:|   ::
  Fly    65 FVCTSTFMSSAALIEKVR-----ETVDRVQE---QPAKKTKVAE------IEEPSTQESD---KK 112

  Fly   304 SDRIEVRNELLE---------PDADESGTQEQTVSEEVS---KK--KAGTRGAAELCEDYI---- 350
            :.::..:|..|.         |.:..:|....|..|.:|   ||  |...:..:.|.||.:
  Fly   113 AVKVPKKNTTLRQRSKSIAAFPPSFVNGANTNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSV 177

  Fly   351 -------------------------------------------------HYMCPDCGTDCDTHAQ 366
                                                             ::.||    :|:.||:
  Fly   178 KLTPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPITINTNNFQCP----ECEFHAK 238

  Fly   367 ----WSQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKL 427
                :.:|::..|.                                        |.:|....|.|
  Fly   239 FPKPYKEHLQKEHG----------------------------------------LQRPRIYPCTL 263

  Fly   428 CYKGYTDHQEIIRHLLQQHHMDTLMSE---------------------DAEEEDGDAPS------ 465
            |.|.:...:.:..| |:..|..|..||                     ||:.::.:|.|
  Fly   264 CIKTFGVLKTLKNH-LRDTHSRTFESEAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKPK 327

  Fly   466 -----------------AIEDECDGDNGNGEGNGAPLDEDSPYFEDAPR-RGGRISS-------- 504
                             .:.||.|....|.:|.      ||   |||.: :..:|:|
  Fly   328 EKKSKEKKTEIKCNVETKVVDEIDDQVNNKKGT------DS---EDADQTQATKIASFKALNESL 383

  Fly   505 ------DDIFE--------------PHID---YLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLN 546
                  :::.:              |..|   :.|..|..|.:..|..:.|:...||::
  Fly   384 MKKRMLENVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSID------ 442

  Fly   547 FEMINERQLKCTECDKIITNAYGIQNAQQHRITH-----LPFKAYARCRKCHKSYTDRKGLVKHL 606
                ..:..||..|:|.:...   |:.:.|...|     .|..:..:..:......|..|..:..
  Fly   443 ----KPKVFKCHVCEKSLATK---QSLKTHMTLHADGAEAPNSSKRKILQDEDEDVDILGTTQIE 500

  Fly   607 ATHHRVGWPRKLSGGCPAPILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQ---- 667
            .|..:|..|:| |...|.   ..||...::|:...:|..||:.....|....:::....|:
  Fly   501 NTAEKVEGPKK-SQQSPT---KAAKFTNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRS 561

  Fly   668 ---MQAEEDEYPIAPPPPSPPPPPQ-------PTTQGNHQRYKCVHCGTLFATQAAVRVHISEKR 722
               :|.:.|...|||..|:......       .||.||....                   ||||
  Fly   562 RNNIQHQVDGGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAK-------------------SEKR 607

  Fly   723 CRKTVVRRRRQPVMSSADPSVPTVEQ-NY---------------------IFLCPSCGFEYKTQF 765
            .::.    :.:..:.|:|  |..||: ||                     ...|..||...|::.
  Fly   608 KKQD----KSEDTLPSSD--VDIVEEINYNVRPHKKARLESIGDSTADESTLSCDRCGKFVKSRQ 666

  Fly   766 EWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDH--HFRHLPYRLYLKCLI 828
            ....|:.:.|              ..:.|||.||::..|.     .|:  ||.:......|.|.:
  Fly   667 RLDSHMEKKH--------------AAKLQCTLCKEVYQNQ-----MDYVAHFSNCGSEGGLPCGV 712

  Fly   829 --CGTCYNHKPNIAAHLRARH 847
              |...:.....:::|||.||
  Fly   713 ANCKKVFTEANFLSSHLRKRH 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368	5/38 (13%)
		C2H2 Zn finger	235..256	CDD:275368	3/20 (15%)
		C2H2 Zn finger	516..532	CDD:275368	4/15 (27%)
		C2H2 Zn finger	557..580	CDD:275368	5/22 (23%)
		C2H2 Zn finger	589..609	CDD:275368	2/19 (11%)
		COG5236	<939..>1096	CDD:227561
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/20 (25%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930