DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG31612

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001163042.1	Gene:	CG31612 / 35427	FlyBaseID:	FBgn0051612	Length:	987	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	217/1140 - (19%)
Similarity:	348/1140 - (30%)	Gaps:	441/1140 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DEREEEDDYEKNSKEPKQPDPDDDALFDFNMEPIVDIAEPQRPSLAPAGPMSQQVRPPMQRHSFP 126
            ||.::||::|:...|      :|:..:|         |....|.:.||.....:.:|..
  Fly   179 DEEDDEDEHEEFDAE------EDEEEYD---------ARRHSPPIVPASHTGGKWKPEQ------ 222

  Fly   127 GAGGRPRLGSGLSVRPTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYN 191
                ||:|......|.:.|.....:||           |..|..       ||.|.
  Fly   223 ----RPQLRHPHIERLSPSWDEPPEEN-----------YTHPPA-------DHTKG--------- 256

  Fly   192 TLRGLNFTPLDKLYQRCRECNKRIAMHSRENLLKHKFTHLPFRCTKCYICKREYKYRQDLMVHLR 256
                 .:.|..|            .:..||||...|... |.....|.||.|..|.|.....||
  Fly   257 -----KWVPGSK------------QLEYRENLDLTKLDQ-PGASYWCNICCRRLKSRLYYNQHL- 302

  Fly   257 MVHCDEVVAMMREGYNAAGRKTRVRESRTEQ--LLREKSFRENDDLGEESDRIEVRNELLEPDAD 319
                       |.||:.   |....|...||  |.||.:..::..:.:::|    :||...|
  Fly   303 -----------RSGYHI---KRAEAECELEQATLGRELTLSKDFSIKDDAD----KNEPKPP--- 346

  Fly   320 ESGTQEQTVSEEVSKKKAGTRGAAELCEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLN 384
                         .:::.......:||.   |.|              ::|:...| .:|.  .:
  Fly   347 -------------KRQRRANLLRCDLCR---HTM--------------ARHLIGKH-LISH--YH 378

  Fly   385 FRSVDMQ------------------------MQCLECKKIVTPNTIKSLRAHKFSH--------L 417
            ||.:..|                        .||:.|:  ...||.::...|..||        |
  Fly   379 FRRLQQQSRIRRQACLQEILKHMGSIVRQSPFQCMPCR--FYANTEETFLYHWKSHEHLELTKRL 441

  Fly   418 SQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNG 482
            ....|  |..|......:..::.|||...|.:.|::.:.     ..|..|
  Fly   442 GGTFW--CSFCQFNSNTNNSMLLHLLDSSHKEVLLALNR-----SVPICI--------------- 484

  Fly   483 APLDEDSPYFEDAPRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNF 547
                        |.||  ||.            |.:||.||:.....|.|.:..|....|:....
  Fly   485 ------------AQRR--RIQ------------CSRCGMEFLYNIQLRQHSITEHPGLALTGTAA 523

  Fly   548 EMINERQLKCTECDKIITNAYGIQNAQQHRITHLPFKAYAR--CRKCHKSYTDRKGLVKH--LAT 608
            :....| .:|..|.....:...:|..::|: .||     ||  |..|...:.:.....:|  |..
  Fly   524 DEYQSR-FRCNLCGSSQKSRLALQRHKKHK-HHL-----ARYFCAICRLEFDNSLDARRHRSLVI 581

  Fly   609 HHRVGWPRKLSGGCPAPILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEED 673
            |.:...|:           |...||..:|                            |.|..|..
  Fly   582 HKQKARPQ-----------TSIPQPENEI----------------------------EHMLREVL 607

  Fly   674 EYPIAPPPPSPPPPPQPTTQGN------------------HQ-------RYKCVHCGTLFATQAA 713
            |..:      |.||.:.:...|                  ||       .:.|:.||..|.:..|
  Fly   608 EETV------PSPPAKRSADVNAKCSNSRKTIESSQRLAQHQAEVHSSDNHLCLSCGISFESAQA 666

  Fly   714 VRVHISEKRCRKTVVRRRRQPVMSSADPS-VPTVEQNYIFLCPSCGF--EYKTQFEWRR--HI-- 771
            :..|           .|..||:.|::.|: :...::..::.|..|.|  :|::...:.|  |.
  Fly   667 LGRH-----------TRSCQPLASTSTPADLSQAQKKSMYSCDQCRFQSQYESDLVYHRIFHTRS 720

  Fly   772 -----NEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLICGT 831
                 |||                  .||..|..   |.|...|:.|...|...::: :|..|..
  Fly   721 GTIGKNEV------------------LQCPLCPK---NFKKHSLRAHLRNHTNEKIF-ECTECLQ 763

  Fly   832 CYNHKPNIAAHLRARHS-IFDRETPTMITKPKQVLGRYKDNSRENPKLPSPPPAPALAPAPPSPP 895
            .:..:.|:..|:..:|: :.|:|      |.|...   ||..:..||.
  Fly   764 KFARRHNLKNHVITKHAKVGDKE------KKKYAA---KDVEQSKPKY----------------- 802

  Fly   896 ACSSSAAASASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVDLDFITYF--CPKCNQNFDSHAF 958
            .|.:.....|...|||..                .||:..||:.:::.:|  |....:..:|
  Fly   803 QCGTCGKLLAKKYSLKLH----------------EISHSKAVERNYLCHFADCSYAGRTPES--- 848

  Fly   959 WRKHIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHL--PHRS--- 1018
            .:.|:|.    :|:|        ||....:.|          ..:|:.:.|..|||  .|.:
  Fly   849 LKTHLVS----HSQE--------NHKCARINC----------SYVGKSELHLKRHLKSAHSTEKN 891

  Fly  1019 ----FKCLTCG------GEFVRKQMFFKHLNRDTNRCDNRPHREFDDDEPD--QDTLLST----- 1066
                |.|..|.      |...|..:  :|..:..::|   ||.:|.....|  :..::.|
  Fly   892 GEEWFSCDQCDFRARIKGHLRRHSL--RHSGQKPHQC---PHCDFQCSTIDNLRKHIIKTGKHPG 951

  Fly  1067 --IYHLTCPQCGDN-----FKTHNKKEWREHINDH 1094
              |||  |.:|.|.     ||:::.||::.|:..|
  Fly   952 MFIYH--CAKCSDEEAGEIFKSNSYKEYQHHLKTH 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	4/20 (20%)
		C2H2 Zn finger	208..230	CDD:275368	5/21 (24%)
		C2H2 Zn finger	235..256	CDD:275368	7/20 (35%)
		C2H2 Zn finger	516..532	CDD:275368	6/15 (40%)
		C2H2 Zn finger	557..580	CDD:275368	4/22 (18%)
		C2H2 Zn finger	589..609	CDD:275368	4/21 (19%)
		COG5236	<939..>1096	CDD:227561	40/187 (21%)
CG31612	NP_001163042.1	C2H2 Zn finger	697..717	CDD:275368	5/19 (26%)
		C2H2 Zn finger	731..750	CDD:275368	6/21 (29%)
		C2H2 Zn finger	758..779	CDD:275368	4/20 (20%)
		C2H2 Zn finger	804..824	CDD:275368	6/35 (17%)
		C2H2 Zn finger	834..856	CDD:275368	5/28 (18%)
		C2H2 Zn finger	898..918	CDD:275368	4/21 (19%)
		zf-H2C2_2	910..935	CDD:290200	6/29 (21%)
		C2H2 Zn finger	926..945	CDD:275368	5/21 (24%)
		C2H2 Zn finger	957..984	CDD:275368	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100