DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG12299

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	146/922 - (15%)
Similarity:	250/922 - (27%)	Gaps:	397/922 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDFEEGEAESGVAELEDSEQYGNGNDDFLGDTAILDSGDAIDDLLDAEEDEREEEDDYEKNSKEP 77
            ||..:|.|.||    .||....:.:||...|.:...|..:.:....:.........:.:: |:|.
  Fly   107 SDSSDGSASSG----SDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTTSNSNTQQ-SQES 166

  Fly    78 KQP------------------DPDDDALFDFNMEPIVDIAEPQRPSLAPAGPMSQQVRPPMQRHS 124
            .||                  ||.:.... |.::|.|.:.           |: ||:.||....|
  Fly   167 VQPLHGLVAGPGYNEFQLQMTDPRESTSI-FMVQPTVSVT-----------PL-QQLLPPAPTVS 218

  Fly   125 FPGAGGRPRLGSGLSVRPTTSQINATDENGVPI-------NYELGVVYICPACGGEFRQQDHWKR 182
             ||.        ||...|...:.......|.|:       |.:   .:.|..|...|.......:
  Fly   219 -PGL--------GLQSTPIKRRRGRRSNIGAPVMDPALNGNQK---CFQCTHCEASFPNAGDLSK 271

  Fly   183 HM-NHIHKYNTLRGLNFTPLDKLYQRCRECNKRIAMHSRENLLKHKFTHLPFRCTKCYICKREYK 246
            |: :||    |.:....:...|.:......|..|.:||.|.         |:   ||.:|.:.:.
  Fly   272 HVRSHI----TNKPFQCSICQKTFTHIGSLNTHIRIHSGEK---------PY---KCELCPKAFT 320

  Fly   247 YRQDLMVHLR---------MVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDLGE 302
            ....||||:|         .|.||:  ..:........:||.:..:.|
  Fly   321 QSSSLMVHMRSHSVRKPHQCVQCDK--GFINYSSLLLHQKTHIAPTET----------------- 366

  Fly   303 ESDRIEVRNELLEPDADESGTQEQTVSEEVSKKKAGTRGAAELCEDYIHYMCPDCGTDCDTHAQW 367
                                                             ::||:|..:....|..
  Fly   367 -------------------------------------------------FICPECEREFKAEALL 382

  Fly   368 SQHIEFVHDYVSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKLCYKGY 432
            .:|                                      :|.|     :|....:|.:|.:.:
  Fly   383 DEH--------------------------------------MRMH-----TQELVYQCAICREAF 404

  Fly   433 TDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDEDSPYFEDAPR 497
            ....|:::|:  ::||            |:.|
  Fly   405 RASSELVQHM--KNHM------------GEKP--------------------------------- 422

  Fly   498 RGGRISSDDIFEPHIDYLCPQCGKEFIEKK----HWRTHVVMAHSMNDLSKLNFEMINERQLKCT 558
                            :.|..|.:.|.:..    |.|.|.                 .|:..:|.
  Fly   423 ----------------FTCSLCDRSFTQSGSLNIHMRIHT-----------------GEKPFQCK 454

  Fly   559 ECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCP 623
            .|||..|.|   .:...|...|...|.|. |..|.|||:.:..|.||:..|...    ..:....
  Fly   455 LCDKCFTQA---SSLSVHMKIHAGEKPYP-CPICGKSYSQQAYLNKHIQAHQMA----SAASAST 511

  Fly   624 APILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPP 688
            :|.|..||||
  Fly   512 SPGLLVAKQP------------------------------------------------------- 521

  Fly   689 QPTTQGNHQRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSA-DPSVPTVEQNYIF 752
                   |:...|:.||:|.|...|:..|:..:..  .::...:|..|::| ..::|.|:
  Fly   522 -------HETLVCIVCGSLHADATALASHVHSQHA--ALLDTMKQSGMNTAPGGAIPDVK----- 572

  Fly   753 LCPSCGFEYKTQFEWRRHINEVH------NFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQ 811
                |..|     |.:.::..|.      |..::...:.:|..:.:.|..|.:           |
  Fly   573 ----CSAE-----EQQAYVERVQCVLQQMNHQQQHQQHQQQPPQQQQQHPQQQ-----------Q 617

  Fly   812 DHHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENP 876
            ..|.:..|:::.|.         .:|.:.|......   |.|.|....:|..     ::..::.|
  Fly   618 QQHLQQQPHQMQLP---------QQPKLPAMDSTGE---DEEEPDEAEEPPD-----EEEEQDEP 665

  Fly   877 KLPSPPPAPALA 888
            :.|:......||
  Fly   666 EEPAEVKTEVLA 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	5/21 (24%)
		C2H2 Zn finger	208..230	CDD:275368	5/21 (24%)
		C2H2 Zn finger	235..256	CDD:275368	7/20 (35%)
		C2H2 Zn finger	516..532	CDD:275368	5/19 (26%)
		C2H2 Zn finger	557..580	CDD:275368	7/22 (32%)
		C2H2 Zn finger	589..609	CDD:275368	8/19 (42%)
		COG5236	<939..>1096	CDD:227561
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	39/285 (14%)
		C2H2 Zn finger	256..276	CDD:275368	4/19 (21%)
		zf-H2C2_2	268..293	CDD:290200	5/28 (18%)
		C2H2 Zn finger	284..304	CDD:275368	3/19 (16%)
		zf-H2C2_2	296..321	CDD:290200	9/36 (25%)
		zf-C2H2_2	312..>387	CDD:289522	18/180 (10%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	4/21 (19%)
		C2H2 Zn finger	369..389	CDD:275368	6/57 (11%)
		C2H2 Zn finger	397..417	CDD:275368	4/21 (19%)
		zf-H2C2_2	409..434	CDD:290200	9/87 (10%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		zf-H2C2_2	437..462	CDD:290200	8/41 (20%)
		C2H2 Zn finger	453..473	CDD:275368	7/22 (32%)
		zf-H2C2_2	465..490	CDD:290200	9/25 (36%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100