DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG4496

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001285707.1	Gene:	CG4496 / 34000	FlyBaseID:	FBgn0031894	Length:	580	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	131/660 - (19%)
Similarity:	216/660 - (32%)	Gaps:	226/660 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   546 NFEMINERQLKCTECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDR----------- 599
            ||..|::.::|          ::..|..||.|...|..|......|..|...:|
  Fly    56 NFISIDDVKIK----------SFLWQIGQQQREKELEIKRIMEQEKREKREKERREAEKRRDQEV 110

  Fly   600 -----------KGLVKHLATHHRVGWPRKLSGGCPAPILTPAKQPRKQIVTVANETYEIIYLDDV 653
                       :||:.. |......|...:....|...|.|.:..|    .||.     |.|.|.
  Fly   111 IELDEEEAQSPRGLIIS-AARSLAHWNSSIRRVTPDIELIPRRVHR----VVAE-----IELSDS 165

  Fly   654 DQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQGNHQRYKCVHCGTLFATQAAVRVHI 718
            |.   :||::..|.:..               |....:...|.||..    |:....:..:.|..
  Fly   166 DH---DEDSEVDEDVSL---------------PSNAVSCVLNEQRQD----GSQNPQELVIIVPS 208

  Fly   719 SEKRCRKT--VVRR---------RRQPVMSSADPSVPTVEQNYIFLCPSCGFEYKTQFEWRRHIN 772
            .::..:||  |::|         :|:|..:.        ...:::.||.||.:.::.:..|||:
  Fly   209 DQEDEQKTDNVIKRKSSGSRRLVKRRPGANR--------RGRHMYECPDCGKKVQSNYNLRRHM- 264

  Fly   773 EVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDHHFRHLPYRLYLKCLICGTCYNHKP 837
            .:|..::            .:.|..|:...  .:...|:.|..||.....:: |:||
  Fly   265 MIHTGER------------PFPCDLCERRF--REFSDLKKHRRRHSHDPQFI-CMIC-------- 306

  Fly   838 NIAAHLRA-----RHSIFDRETPTMITKPK-QVLG----------------RYKDNSRENPKLP- 879
                ||.|     .....|.|:..::.||: :.||                ..::.:.||.|.|
  Fly   307 ----HLGAPLEQDSTRCADCESKNLMVKPQPEELGEKTTEEHSDEMEGDDDEIEEAALENEKQPQ 367

  Fly   880 ----------------SPP---PAPALAPAPPSPPACSSSAAASASSRSLKPQPGGLPARPAGLN 925
                            |||   |:......||.|.:|||:.::|:.|..     |.:    ||.:
  Fly   368 VATQPSLMVTLIPPIQSPPEKVPSHTQPSRPPLPRSCSSANSSSSLSND-----GNI----AGKS 423

  Fly   926 TLEDSISYHNAVDLDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYL---- 986
            ......||.           ||.|::.|.:          :||.            ..||:
  Fly   424 MSRTRRSYP-----------CPLCHRPFGT----------RHNL------------KRHYMIHTG 455

  Fly   987 -----CLECYKRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDTNRCD 1046
                 |.:|.|......|      |:.|...|:..|.:|||.|..:|.....:..|.|...::..
  Fly   456 EKPFSCSKCRKPFRECST------LKKHMVTHVRDRWYKCLRCPSKFRDYLEYSDHKNNHQDQLS 514

  Fly  1047 NRPHREFDDDEPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWREHINDHHGLTKLELLHMTKVGED 1111
            :|....::.|: |.|:.:...  |.|.:|...|.  ....:..|:..|    .|||..|:.  :|
  Fly   515 SRKSSIYESDD-DGDSSVEDC--LECCECQQRFT--ELDAYTAHLKKH----DLELYGMSI--DD 568

  Fly  1112 VYRCQDCDEE 1121
            |     .|||
  Fly   569 V-----ADEE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368
		C2H2 Zn finger	557..580	CDD:275368	4/22 (18%)
		C2H2 Zn finger	589..609	CDD:275368	6/41 (15%)
		COG5236	<939..>1096	CDD:227561	33/165 (20%)
CG4496	NP_001285707.1	zf-C2H2	245..267	CDD:278523	7/22 (32%)
		C2H2 Zn finger	247..267	CDD:275368	7/20 (35%)
		zf-H2C2_2	259..282	CDD:290200	6/35 (17%)
		C2H2 Zn finger	275..295	CDD:275368	4/21 (19%)
		zf-C2H2	431..453	CDD:278523	9/54 (17%)
		C2H2 Zn finger	433..453	CDD:275368	8/41 (20%)
		zf-H2C2_2	445..468	CDD:290200	6/34 (18%)
		C2H2 Zn finger	461..481	CDD:275368	6/25 (24%)
		C2H2 Zn finger	489..510	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100