DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and CG8944

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	768	Identity:	146/768 - (19%)
Similarity:	234/768 - (30%)	Gaps:	297/768 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ELEDSEQYGNGNDDFLGDTAILDSGDAI-----------DDLLDAEEDEREEE-DDYEKNSKEPK 78
            |:||...         .|||:|:....|           ||::..|||:.|:. :|.|.:..|..
  Fly    94 EIEDLTD---------ADTALLEPQMVIKQELQDLPCSDDDVVAGEEDDDEQRLNDSEADEDEAI 149

  Fly    79 QPDPDDDALFDFNMEPIVDIAEPQRPSLAPAGPMSQQVRPPMQRHSFPGAGGRPRLGSGLSVRPT 143
            .|:.|         .|:|......|..:.     .|:.|.........|.|.
  Fly   150 LPESD---------VPVVSSKTRARKKVT-----KQRQRDMSSELLIAGDGD------------- 187

  Fly   144 TSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLN---------FT 199
                ::.|:.|.|.:..:               .|:...:|:    :....|:|         |.
  Fly   188 ----SSMDDYGDPDHSYM---------------DDNSGEYMD----FAGFDGVNHSGFGTESDFL 229

  Fly   200 PLDKLYQ-----RCRECNKRIAMHSRE----NLLKHKFTHLPF-----------RCTKCYICK-- 242
            ..|::.:     |.||    :.||.::    ..|.|.:...||           |..:.....
  Fly   230 SYDEMVEESLLGRDRE----VTMHIKDRKMIQFLIHSYQRNPFLWDHGNAQFRDRVKRARFLDWI 290

  Fly   243 -REYKYRQDLMV----------HLRMVHCDEVVAMMREGYNAAGRKTRV---------------- 280
             .|:|.|.::.:          :||.|:       .||....|..||.:
  Fly   291 VLEFKSRFNISLAKDAITRKWDNLRTVY-------KRECNRMALEKTNISTLWYFKELHFLNEVY 348

  Fly   281 --RESRTEQLLREKSFRE------ND----DLGEESDRIEVRNELLEPDADESGTQEQTVSEEVS 333
              .:..::.:::|.|:|.      ||    .|.....|.:......:||..             |
  Fly   349 SYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNRFDPDYR-------------S 400

  Fly   334 KKKAGTRGAAELCEDYIHYMCPDCGTDCD-THAQWSQHI----------------------EFVH 375
            |::.|         :.:|.|..:.....| |..|.|:.|                      :|:.
  Fly   401 KERRG---------EGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKFIA 456

  Fly   376 DYVSRRGLNFRSVDM-QMQCLECKKIVTPNTIKSLRAHKFSHLSQPEW----------------- 422
            :|:....::|...|: ..:|..|.:||  .|::.|..|..:|  ||..
  Fly   457 NYLYYDQMHFMDDDIPPFKCAHCPEIV--QTLRELDLHMLTH--QPSLGGGYYCNICSIQFHNAQ 517

  Fly   423 -----------------LRCKLCYKGYTDHQEIIRHL-----------LQQHHM-------DTLM 452
                             ..|:||...:.:......||           |..:|.       |..:
  Fly   518 EFDNHKQLHLGGVTEIKFNCELCTASFREKANYDEHLRRHNEELFLPSLALNHSIMEGGLGDDEI 582

  Fly   453 SEDAEEEDGD--------APSAIEDECDGDN-----GNGEGNGAPLDEDSPYFEDAPRRG----G 500
            ..:.||..|.        |..|.:|..|.|:     |.|...|...|...||..|..||.    |
  Fly   583 GVEGEESRGSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCDVCRRSFATPG 647

  Fly   501 RISSDDIFEPHID-----YLC--PQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQLKCT 558
            .:::..|.  |.|     |.|  |||.|.|:.:.....|:...:|            || :.||.
  Fly   648 HLNAHRIV--HQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYS------------NE-EFKCD 697

  Fly   559 ECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHR 611
            .|.|...:.   :|.|.|:..|...|.|. |:.|..::....||..|...|:|
  Fly   698 ICGKTFKST---KNLQNHKQIHDKIKRYV-CQICGSAFAQAAGLYLHKRRHNR 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	2/20 (10%)
		C2H2 Zn finger	208..230	CDD:275368	6/25 (24%)
		C2H2 Zn finger	235..256	CDD:275368	3/33 (9%)
		C2H2 Zn finger	516..532	CDD:275368	6/17 (35%)
		C2H2 Zn finger	557..580	CDD:275368	6/22 (27%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		COG5236	<939..>1096	CDD:227561
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	16/91 (18%)
		MADF	379..472	CDD:214738	18/114 (16%)
		C2H2 Zn finger	476..496	CDD:275368	7/21 (33%)
		C2H2 Zn finger	506..526	CDD:275368	0/19 (0%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	636..656	CDD:275368	5/21 (24%)
		zf-C2H2_8	639..712	CDD:292531	23/90 (26%)
		C2H2 Zn finger	666..688	CDD:275368	7/21 (33%)
		zf-C2H2	694..716	CDD:278523	7/24 (29%)
		C2H2 Zn finger	696..716	CDD:275368	6/22 (27%)
		zf-H2C2_2	708..733	CDD:290200	8/25 (32%)
		C2H2 Zn finger	724..744	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930