DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6791 and CG12219

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_572312.1	Gene:	CG12219 / 31572	FlyBaseID:	FBgn0043796	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	119/623 - (19%)
Similarity:	175/623 - (28%)	Gaps:	231/623 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 LCEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDYVSRRGLNFRSVDMQMQCL----ECKKIVTPNT 405
            ||..::       ..|||.:  ||:.           | :...:|.|.|.|    |..|:|||.|
  Fly    91 LCSQFL-------AIDCDVN--WSED-----------G-SETQLDAQPQLLLEPAEEPKVVTPTT 134

  Fly   406 IKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDE 470
                 |:||.         |..|.|.:.     :|..|::|         .....||.|.|
  Fly   135 -----ANKFP---------CMFCEKSFK-----MRRYLEEH---------IATHTGDRPIA---- 167

  Fly   471 CDGDNGNGEGNGAPLDEDSPYFEDAPRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVM 535
                                                         ||.|...|..:.:..|||..
  Fly   168 ---------------------------------------------CPYCEMAFRCRSNMYTHVKS 187

  Fly   536 AHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQNAQQHR---------ITHLPFKAYARCRK 591
            .|:.        :.:..|:    |.|...:|       |.|.         :..:|..|.| ...
  Fly   188 KHTT--------QWLKARE----ERDAAKSN-------QNHTTPEETAPAVLVPVPAPAPA-LAS 232

  Fly   592 CHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPAPILTP---AKQPRKQIVTVANETYEIIYLDDV 653
            ...|.......|...||..........:....||:.:|   .:.|...|.:..:|...:......
  Fly   233 APASSASPGNTVNPAATATPASSATPTTNLAAAPLPSPPTVQQLPLSVIKSQPSEAMNLTITKTP 297

  Fly   654 DQG-----------------------GMEEDNDFGEQMQAEEDEY-----------PIAPPPPSP 684
            ..|                       |.:..::...|.:.:|:|.           .:|....:.
  Fly   298 PSGSRGSRNRSSRRKTHSPKKVQHTEGSDVSDEDSPQKRLKENELILANYNAVAAAVVAAASLTG 362

  Fly   685 PPPPQPTTQGNHQRYKCV------HCGTLFATQ-----AAVRVHISEKRCRKTVVR--------R 730
            .||.||.:.   |:..|.      |...|||..     ||..|..|......|...        .
  Fly   363 NPPGQPDSL---QQRLCASLLQQQHQEQLFAVMSATAAAAAAVGTSSATTTTTTTTGTMMAHPYG 424

  Fly   731 RRQPVMSSADPSVPTVEQNYI------FLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLD 789
            ...|..:...|:.|.  |..|      .:||:|| |...|                   |.|.|.
  Fly   425 NHPPSETDKRPAAPL--QAVIHAAPVSIICPNCG-ELPGQ-------------------NHRCLS 467

  Fly   790 KYRYQCTQCKDIVCNSKLK---GLQDHHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSI-F 850
            |.:|.|.     ||....|   .|::|...|...:|: .|..|.|.:..|.|:..|.:.:|.. :
  Fly   468 KPKYACD-----VCGKSFKMKRYLEEHFATHTGVKLH-TCAFCPTEFRSKSNMYHHTKRKHKAEW 526

  Fly   851 DRETPTMITKPKQVLGRYKDNSRENPKLPSPPPAPALA 888
            :|   :..|:.....|..:.....||......|.||.|
  Fly   527 ER---SRATRSAAKAGVQEQMQHTNPSQAQAQPGPAAA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368	4/15 (27%)
		C2H2 Zn finger	557..580	CDD:275368	5/31 (16%)
		C2H2 Zn finger	589..609	CDD:275368	3/19 (16%)
		COG5236	<939..>1096	CDD:227561
CG12219	NP_572312.1	zf-AD	2..94	CDD:285071	2/2 (100%)
		C2H2 Zn finger	140..160	CDD:275368	6/33 (18%)
		COG4049	149..204	CDD:226535	18/124 (15%)
		C2H2 Zn finger	168..186	CDD:275368	6/17 (35%)
		C2H2 Zn finger	473..493	CDD:275370	6/24 (25%)
		C2H2 Zn finger	501..522	CDD:275370	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930