DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6791 and Zfp160

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_663458.2	Gene:	Zfp160 / 224585	MGIID:	108187	Length:	650	Species:	Mus musculus

Alignment Length:	934	Identity:	168/934 - (17%)
Similarity:	260/934 - (27%)	Gaps:	400/934 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 RVRESRTEQLLREKSFRENDDLGEESDRIEVRNELLEPDAD-ESGTQEQTVSE-------EVSKK 335
            |.|:|..::.:|..| .||.: |.|:..|...:.:|..|.. .||.:...|.|       .:..:
Mouse    75 RTRKSNGKEYIRAMS-AENIN-GNEAKSISSGSSILSSDKILASGDKAPVVHEYDVYSSLRIKGQ 137

  Fly   336 KAGTRGAAELCED---------------YIH-----YMCPDCGTDCDTHAQWSQHIEFVHDYVSR 380
            ||..:|....|::               .||     |.|.:||     .|.:.:....||:
Mouse   138 KATIKGKPYQCKECDKVFSYTSSLAYHRQIHTGEKLYKCLECG-----KAFFRRSYLLVHE---- 193

  Fly   381 RGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQ 445
               ...:.....:|.||.|:.:.|:  .|::|:..|..:..: :|..|.|.::....:..|  |.
Mouse   194 ---RHHTGAKPYKCNECGKVFSQNS--HLKSHRRIHTGEKPF-KCNHCGKAFSVRSNLTHH--QV 250

  Fly   446 HHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDEDSPYFEDAPRRGGRISSDDIFEP 510
            .|            .||.|
Mouse   251 IH------------TGDKP---------------------------------------------- 257

  Fly   511 HIDYLCPQCGKEFIEKK----HWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQ 571
               |.|.:|||.|.:..    |.|||.                 .|:..:|.||.|:.::.   .
Mouse   258 ---YKCNECGKVFSQTSSLTIHRRTHT-----------------GEKPYRCNECGKVFSSH---S 299

  Fly   572 NAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPAPILTPAKQPRKQ 636
            |...|:..|...|.| :|.:|.|.:|..    .|||.|.|:
Mouse   300 NLNTHQAIHTGEKPY-KCSECGKVFTQN----SHLANHWRI------------------------ 335

  Fly   637 IVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQGNHQRYKC 701
                                              ...|.|                      |||
Mouse   336 ----------------------------------HTGEKP----------------------YKC 344

  Fly   702 VHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSADPSVPTVEQNYIFLCPSCGFEYKTQFE 766
            ..||..|:..:::..|               |.:.:...|          :.|..||..:.....
Mouse   345 NECGKAFSVYSSLTTH---------------QAIHTGEKP----------YKCNECGKVFTQNSH 384

  Fly   767 WRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLKGLQDH---HFRHLPYRLYLKCLI 828
            ...| ..||:.:|            .|:|.:|..:.  |:...|..|   |....||    ||..
Mouse   385 LASH-RGVHSGEK------------PYKCEECGKLF--SQTSNLARHWRVHTGEKPY----KCSE 430

  Fly   829 CGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENPKLPSPPPAPALAPAPPS 893
            ||..::.:.::.||    ..|...|.|...|:..:|..:
Mouse   431 CGKAFSVRSSLIAH----QVIHTGEKPYKCTECGKVFSQ-------------------------- 465

  Fly   894 PPACSSSAAASASSRSLKPQPGGLPARPAGLNTLEDSISYHNAVDLDFITYFCPKCNQNFDSHAF 958
                                              ..|:|.|..:......|.|.:|.:.|:||:
Mouse   466 ----------------------------------TSSLSIHQRIHTGEKPYRCNECGKAFNSHS- 495

  Fly   959 WRKHIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLT 1023
                     |.|:.:.::..|   ..|.|::|.|..|..      ..|.:|:..|...:.:||..
Mouse   496 ---------NLNTHQVIHTGQ---KPYKCMQCGKVFTQN------SHLANHQRTHTGEKPYKCNE 542

  Fly  1024 CGGEFVRKQMFFKHLNRDTNRCDNRPHREFDDDEPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWR 1088
            ||..|........|....|.   .:|::                    |.:||..| |.|
Mouse   543 CGKAFSVYSSLTTHQAIHTG---EKPYK--------------------CNECGKVF-TQN----- 578

  Fly  1089 EHINDHHGLTKLELLHMTKVGEDVYRCQDCDEELETNRQWVLQFHRFQHLPHAAYIRCKLCKQSS 1153
            .|:..|         ..|..||..|:|..||:.......  |..|:..|.....| .|..|
Mouse   579 SHLASH---------RRTHTGEKPYQCNKCDKAFSVRSS--LTTHQAIHTGEKPY-TCSEC---- 627

  Fly  1154 ADGADAVGELHS-LRELQQHIRKH 1176
                   |::.| ...|..|.|.|
Mouse   628 -------GKVFSRSSNLTSHQRLH 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368	7/19 (37%)
		C2H2 Zn finger	557..580	CDD:275368	6/22 (27%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		COG5236	<939..>1096	CDD:227561	33/156 (21%)
Zfp160	NP_663458.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	148..168	CDD:275368	1/19 (5%)
		C2H2 Zn finger	176..196	CDD:275368	6/31 (19%)
		zf-H2C2_2	188..213	CDD:290200	6/31 (19%)
		COG5048	200..635	CDD:227381	135/784 (17%)
		zf-C2H2	202..224	CDD:278523	7/23 (30%)
		C2H2 Zn finger	204..224	CDD:275368	7/21 (33%)
		zf-H2C2_2	216..240	CDD:290200	6/24 (25%)
		C2H2 Zn finger	232..252	CDD:275368	5/21 (24%)
		zf-H2C2_2	244..269	CDD:290200	12/87 (14%)
		C2H2 Zn finger	260..280	CDD:275368	7/19 (37%)
		zf-H2C2_2	272..297	CDD:290200	9/41 (22%)
		C2H2 Zn finger	288..308	CDD:275368	6/22 (27%)
		zf-H2C2_2	300..325	CDD:290200	8/25 (32%)
		C2H2 Zn finger	316..336	CDD:275368	9/81 (11%)
		C2H2 Zn finger	344..364	CDD:275368	6/34 (18%)
		zf-H2C2_2	356..381	CDD:290200	6/49 (12%)
		C2H2 Zn finger	372..392	CDD:275368	4/20 (20%)
		zf-H2C2_2	384..409	CDD:290200	7/39 (18%)
		C2H2 Zn finger	400..420	CDD:275368	5/21 (24%)
		zf-H2C2_2	412..436	CDD:290200	9/27 (33%)
		C2H2 Zn finger	428..448	CDD:275368	5/23 (22%)
		zf-H2C2_2	440..465	CDD:290200	7/28 (25%)
		C2H2 Zn finger	456..476	CDD:275368	5/79 (6%)
		zf-H2C2_2	468..493	CDD:290200	7/24 (29%)
		C2H2 Zn finger	484..504	CDD:275368	7/29 (24%)
		zf-H2C2_2	496..521	CDD:290200	7/27 (26%)
		C2H2 Zn finger	512..532	CDD:275368	6/25 (24%)
		zf-H2C2_2	524..548	CDD:290200	7/23 (30%)
		C2H2 Zn finger	540..560	CDD:275368	5/19 (26%)
		zf-H2C2_2	552..577	CDD:290200	7/48 (15%)
		C2H2 Zn finger	568..588	CDD:275368	8/34 (24%)
		zf-H2C2_2	580..604	CDD:290200	9/32 (28%)
		C2H2 Zn finger	596..616	CDD:275368	5/21 (24%)
		zf-H2C2_2	608..633	CDD:290200	7/38 (18%)
		C2H2 Zn finger	624..644	CDD:275368	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832281
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930