DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6791 and ZNF497

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001193938.1	Gene:	ZNF497 / 162968	HGNCID:	23714	Length:	498	Species:	Homo sapiens

Alignment Length:	737	Identity:	147/737 - (19%)
Similarity:	217/737 - (29%)	Gaps:	313/737 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PR-LGSGLSVRPTTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRG 195
            || .|.|...:.|   :.|.||.|.| ..|||     ||.||    :|.              .|
Human    48 PREAGDGQRQQAT---LGAADEQGGP-GRELG-----PADGG----RDG--------------AG 85

  Fly   196 LNFTPLDKLYQ----------RCRECNKRIAMHSRENLLKHKFTHL---PFRCTKCYICKREYKY 247
            ....|.|:..:          ||.||.|..:..|  .||:|:..|.   |:.|.:   |.:.:.:
Human    86 PRSEPADRALRPSPLPEEPGCRCGECGKAFSQGS--YLLQHRRVHTGEKPYTCPE---CGKAFAW 145

  Fly   248 RQDLMVHLRMVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDLGEESDRIEVRNE 312
            ..:|..|.| :|..|.....||    .|                |:||             ..::
Human   146 SSNLSQHQR-IHSGEKPYACRE----CG----------------KAFR-------------AHSQ 176

  Fly   313 LLEPDADESGTQEQTVSEEVSKKKAGTRGAAELCEDYIHYMCPDCGTDCDTHAQWSQHIEFVHDY 377
            |:......||.:.                          :.|||||..........||
Human   177 LIHHQETHSGLKP--------------------------FRCPDCGKSFGRSTTLVQH------- 208

  Fly   378 VSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHL-SQPEWLRCKLCYKGYTDHQEIIRH 441
              ||   ..:.:...:|.||.|..:.|:  :...|:..|. ::|.  .|:.|.|.::....:..|
Human   209 --RR---THTGEKPYECPECGKAFSWNS--NFLEHRRVHTGARPH--ACRDCGKAFSQSSNLAEH 264

  Fly   442 LLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDEDSPYFEDAPRRGGRISSDD 506
            |              :...|..|.|..| |    |......|.|           |:..|..|.:
Human   265 L--------------KIHAGARPHACPD-C----GKAFVRVAGL-----------RQHRRTHSSE 299

  Fly   507 IFEPHIDYLCPQCGKEFIEK----KHWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDK-IITN 566
              :|   :.|.:|||.|.|.    :|.|||.                 .||..:|.||.: .:..
Human   300 --KP---FPCAECGKAFRESSQLLQHQRTHT-----------------GERPFECAECGQAFVMG 342

  Fly   567 AYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPAPILTPAK 631
            :|    ..:||..|...|.:| |.:|.|:::.|..|:.|..||         ||..|
Human   343 SY----LAEHRRVHTGEKPHA-CAQCGKAFSQRSNLLSHRRTH---------SGAKP-------- 385

  Fly   632 QPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQPTTQGNH 696

Human   386 ----------------------------------------------------------------- 385

  Fly   697 QRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSADPSVPTVEQNYIFLCPSCGFEY 761
              :.|..||..|...:.:..|    |...|..|.                     |.|..||..:
Human   386 --FACADCGKAFRGSSGLAHH----RLSHTGERP---------------------FACAECGKAF 423

  Fly   762 KTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQC-KDIVCNSKLKGLQDHHFRHLPYRLYLK 825
            :...|.|:| ..:|:.::            .:.|..| |..|..|:|...:..|....||    .
Human   424 RGSSELRQH-QRLHSGER------------PFVCAHCSKAFVRKSELLSHRRTHTGERPY----A 471

  Fly   826 CLICGTCYNHKPNIAAHLRARH 847
            |..||..::|:.|:..| :.||
Human   472 CGECGKPFSHRCNLNEH-QKRH 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	5/20 (25%)
		C2H2 Zn finger	208..230	CDD:275368	8/21 (38%)
		C2H2 Zn finger	235..256	CDD:275368	4/20 (20%)
		C2H2 Zn finger	516..532	CDD:275368	8/19 (42%)
		C2H2 Zn finger	557..580	CDD:275368	6/23 (26%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		COG5236	<939..>1096	CDD:227561
ZNF497	NP_001193938.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..104		21/82 (26%)
		COG5048	107..492	CDD:227381	124/649 (19%)
		C2H2 Zn finger	108..128	CDD:275368	8/21 (38%)
		zf-H2C2_2	120..144	CDD:290200	7/26 (27%)
		C2H2 Zn finger	136..156	CDD:275368	5/23 (22%)
		zf-H2C2_2	148..171	CDD:290200	9/43 (21%)
		C2H2 Zn finger	164..184	CDD:275368	7/52 (13%)
		zf-C2H2	190..212	CDD:278523	9/33 (27%)
		C2H2 Zn finger	192..212	CDD:275368	9/31 (29%)
		zf-H2C2_2	205..228	CDD:290200	8/34 (24%)
		C2H2 Zn finger	220..240	CDD:275368	6/21 (29%)
		C2H2 Zn finger	248..268	CDD:275368	5/33 (15%)
		C2H2 Zn finger	276..296	CDD:275368	7/35 (20%)
		zf-H2C2_2	289..311	CDD:290200	9/37 (24%)
		C2H2 Zn finger	304..324	CDD:275368	8/19 (42%)
		zf-H2C2_2	317..340	CDD:290200	9/39 (23%)
		C2H2 Zn finger	332..352	CDD:275368	6/23 (26%)
		zf-H2C2_2	344..369	CDD:290200	9/29 (31%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	6/23 (26%)
		C2H2 Zn finger	416..436	CDD:275368	6/20 (30%)
		zf-H2C2_2	428..453	CDD:290200	7/37 (19%)
		C2H2 Zn finger	444..464	CDD:275368	6/19 (32%)
		zf-H2C2_2	456..481	CDD:290200	7/28 (25%)
		C2H2 Zn finger	472..492	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930