DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6791 and LOC100365363

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	187/978 - (19%)
Similarity:	290/978 - (29%)	Gaps:	379/978 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   250 DLMVHL-RMVHCDEVVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDLGE---ESDRIEVR 310
            |.:.|. |.:|.|    :|.|.|:     ..|....|.|.|...|..|.:. |.   ||:.|..|
  Rat    23 DCLDHAQRALHRD----VMLENYS-----NLVSLGMTLQSLNAVSKLEQNK-GPWTVESEAIITR 77

  Fly   311 NELLEPDADESGTQEQTV---SEEVS--KKKAGTRGAAELCEDYIHYMCPDCGTDCDTHAQWSQH 370
                     :|..||..:   :|.:.  :.|:.:.|::.|..|.| ::..|             .
  Rat    78 ---------KSNVQEYAIAMNAENIDCMEAKSISNGSSILSSDRI-FLSGD-------------K 119

  Fly   371 IEFVHDY-----VSRRGLNFRSVDMQMQCLECKKIVTPNTIKSLRAHKFSHLSQPEWLRCKLCYK 430
            ..|||:|     :..:|......:...||.||.|:.  ....||..|:..|..: :..:|..|.|
  Rat   120 APFVHEYDVYSSLLMKGQKAAIKEKPYQCNECDKVF--RYTSSLAYHRQIHTGE-KLYKCVECGK 181

  Fly   431 GYTDHQEIIRHLLQQHHMDTLMSEDAEEEDGDAPSAIEDECDGDNGNGEGNGAPLDEDSPYFEDA 495
            .:.....::.|  ::||            .|..|
  Rat   182 AFFRRSYLLVH--ERHH------------SGAKP------------------------------- 201

  Fly   496 PRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQLKCTEC 560
                              |.|.:|||.|.:..|.::| ...|:            .|:..||.:|
  Rat   202 ------------------YKCNECGKVFSQNSHLKSH-RRIHT------------GEKPYKCNDC 235

  Fly   561 DKIITNAYGIQ-NAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLSGGCPA 624
            .|    |:.:: |...|.:.|...|.| :|.:|.|.::....|..|..||
  Rat   236 GK----AFSVRSNLTHHLVIHTGDKPY-KCNECGKVFSQTSSLTIHRRTH--------------- 280

  Fly   625 PILTPAKQPRKQIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPPSPPPPPQ 689
                ..::|.:     .||..::          ....::..........|.|
  Rat   281 ----TGEKPYR-----CNECGKV----------FSSHSNLNTHQAIHTGEKP------------- 313

  Fly   690 PTTQGNHQRYKCVHCGTLFATQAAV----RVHISEKRCRKTVVRRRRQPVMSSADPSVPTVEQNY 750
                     |||..||.:|...:.:    |.|..||.
  Rat   314 ---------YKCSECGKVFTQNSHLANHWRTHTGEKP---------------------------- 341

  Fly   751 IFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQC-KDIVCNSKLKGLQDHH 814
             :.|..||..:........|: .:|..:|            .|:|.:| |....||.|...:..|
  Rat   342 -YKCNECGKAFSVYSSLTTHL-AIHTGEK------------PYKCEECGKVFTQNSHLANHRGIH 392

  Fly   815 FRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMITKPKQVLGRYKDNSRENPKLP 879
            ....||    ||..||..:|...|:|.|.|    :...|.|            ||
  Rat   393 SGEKPY----KCEECGKHFNQTSNLARHWR----VHTGEKP------------YK---------- 427

  Fly   880 SPPPAPALAPAPPSPPACSSSAAASASSRSLKP----QPGGLPARPAGLNTL---EDSISYHNAV 937
                             ||....|.:...||..    ..|..|.:.|....:   ..|:|.|..:
  Rat   428 -----------------CSECGKAFSVRSSLTSHQVIHTGEKPYKCAECGKVFSQTSSLSIHQRI 475

  Fly   938 DLDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLECYKRVTVTHTKGA 1002
            ......|.|.:|.:.|:||:          |.|:.:.::..|   ..|.||||.|..|..
  Rat   476 HTGEKPYRCNECGKAFNSHS----------NLNTHQVIHTGQ---KPYKCLECGKVFTQN----- 522

  Fly  1003 IGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDTNRCDNRPHREFDDDEPDQDTLLSTI 1067
             ..|.:|...|...:.:||..||      :.|..:.:..|::..:...:.|
  Rat   523 -SHLANHHRTHTGEKPYKCNECG------KAFSVYSSLTTHQAIHTGEKPF-------------- 566

  Fly  1068 YHLTCPQCGDNFKTHNKKEWREHINDHHGLTKLELLHMTKVGEDVYRCQDCDEELE-----TNRQ 1127
               .|.:||..| |.|     .|:..|         ..|..||..|:|..|.:...     |..|
  Rat   567 ---KCNECGKVF-TQN-----SHLASH---------RRTHTGEKPYKCSKCGKAFSVRSSLTTHQ 613

  Fly  1128 WVLQFHRFQHLPHAA---------------YIRCKLCKQSSADGADAVGELHSLRELQQHIRKHH 1177
            .::......|:.:.|               .:..|||:.|.....|::        |.|     |
  Rat   614 AIILEKNLTHVVNVAKSLVEVPTLQVIKDFMLNRKLCQYSKVFRHDSL--------LAQ-----H 665

  Fly  1178 PGL 1180
            ||:
  Rat   666 PGI 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368	2/6 (33%)
		C2H2 Zn finger	516..532	CDD:275368	6/15 (40%)
		C2H2 Zn finger	557..580	CDD:275368	6/23 (26%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		COG5236	<939..>1096	CDD:227561	34/156 (22%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630	15/54 (28%)
		SFP1	<143..221	CDD:227516	25/144 (17%)
		C2H2 Zn finger	148..168	CDD:275368	7/21 (33%)
		C2H2 Zn finger	176..196	CDD:275368	4/21 (19%)
		COG5048	200..575	CDD:227381	112/628 (18%)
		C2H2 Zn finger	204..224	CDD:275368	7/20 (35%)
		C2H2 Zn finger	232..252	CDD:275368	6/23 (26%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		C2H2 Zn finger	288..308	CDD:275368	2/29 (7%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	4/20 (20%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	8/23 (35%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	4/19 (21%)
		C2H2 Zn finger	484..504	CDD:275368	7/29 (24%)
		C2H2 Zn finger	512..532	CDD:275368	8/25 (32%)
		C2H2 Zn finger	540..560	CDD:275368	5/25 (20%)
		C2H2 Zn finger	568..588	CDD:275368	8/34 (24%)
		zf-H2C2_2	580..604	CDD:404364	8/32 (25%)
		C2H2 Zn finger	596..615	CDD:275368	4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335943
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930