DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6791 and ZNF729

DIOPT Version :9

Sequence 1:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	1238	Identity:	242/1238 - (19%)
Similarity:	389/1238 - (31%)	Gaps:	378/1238 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 TTSQINATDENGVPINYELGVVYICPACGGEFRQQDHWKRHMNHIHKYNTLRGLNFTPLDKLYQR 207
            |..:|..|::.  |..|:        .||..|:....:.:| ..||       ...||.     |
Human   224 TKHKIIHTEDK--PYKYK--------KCGNAFKFSSTFTKH-KRIH-------TGETPF-----R 265

  Fly   208 CRECNKRIAMHSRENLLKHKFTHLPFRCTKCYICKREYKYRQDLMVHLRMVH-------CDE--- 262
            |.||.|  |.:...||..||..|...:..||..|.:.:|...:...| :::|       |::
Human   266 CEECGK--AFNQSSNLTDHKRIHTGEKTYKCEECGKAFKGSSNFNAH-KVIHTAEKPYKCEDCGK 327

  Fly   263 ----VVAMMREGYNAAGRKTRVRESRTEQLLREKSFRENDDL--GEESDRIEVRNELLEPDADES 321
                ..|:.:......|:|...||...:...:..:.|:::.:  ||:..:.|           |.
Human   328 TFNHFSALRKHKIIHTGKKPYKREECGKAFSQSSTLRKHEIIHTGEKPYKCE-----------EC 381

  Fly   322 GTQEQTVSEEVSKKKAGTRGAAELCED---------------YIH-----YMCPDCGTDCDTHAQ 366
            |...:..|:....|...|......||:               .||     |.|.:||...::.:.
Human   382 GKAFKWSSKLTVHKVVHTGEKPYKCEECGKAFSQFSTLKKHKIIHTGKKPYKCEECGKAFNSSST 446

  Fly   367 WSQHIEFVH----DYVSRR-GLNFR------------SVDMQMQCLECKKIVTPNTIKSLRAHKF 414
            ..:| :.:|    .|.... |..||            :.:...:|.||.|..  |....||.||.
Human   447 LMKH-KIIHTGEKPYKCEECGKAFRQSSHLTRHKAIHTGEKPYKCEECGKAF--NHFSDLRRHKI 508

  Fly   415 SHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQHHMDTLMSEDAEE--------------EDGDAPS 465
            .|..:..: :|:.|.|.::....:..|.:..........|:..:              ..|:.|.
Human   509 IHTGKKPY-KCEECGKAFSQSSTLRNHQIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPC 572

  Fly   466 AIEDECDGDNGNGEGNGAPL-------DEDSPYFEDAPRRGGRISSDDIFEPH-------IDYLC 516
            ..| ||    |....:.:.|       ..:..|  .....|...::..|...|       ..|.|
Human   573 KCE-EC----GKAFKHFSALRKHKVIHTREKLY--KCEECGKAFNNSSILAKHKIIHTGKKPYKC 630

  Fly   517 PQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQLKCTECDKIITNAYGIQNAQQHRITHL 581
            .:|||.|.:..|...|..: |:            .|:..||.||.|..::...:   ::|:|.|.
Human   631 EECGKAFRQSSHLTRHKAI-HT------------GEKPYKCEECGKAFSHFSAL---RRHKIIHT 679

  Fly   582 PFKAYARCRKCHKSYTDRKGLVKHLATH--------HRVG----WPRKLSGGCPAPILTPAKQPR 634
            ..|.| :|.:|.|:::....|.:|...|        ...|    |..||:   ...::..|::|.
Human   680 GKKPY-KCEECGKAFSHFSALRRHKIIHTGEKPYKCEECGKAFKWSSKLT---VHKVIHTAEKPC 740

  Fly   635 K-----------------QIVTVANETYEIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPP 682
            |                 :::....:.|:.       :..::..|.|...|:
Human   741 KCEECGKSFKHFSALRKHKVIHTREKLYKC-------EECVKAFNSFSALMK------------- 785

  Fly   683 SPPPPPQPTTQGNHQRYKCVHCGTLFATQAAVRV----HISEKRCRKTVVRRRRQPVMSSADPSV 743
                  ........:.|||..||..|...:.:.|    |..||.|:
Human   786 ------HKVIHTGEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCK------------------- 825

  Fly   744 PTVEQNYIFLCPSCGFEYKTQFEWRRHINEVHNFDKRQYLNMRQLDKYRYQCTQCKDIVCNSKLK 808
                      |..||..:|.....|:| ..:|.            .|..|:|.:|....  |:..
Human   826 ----------CEECGKAFKHFSALRKH-KVIHT------------GKKPYKCEECGKAF--SQSS 865

  Fly   809 GLQDHHFRHLPYRLYLKCLICGTCYNHKPNIAAHLRARHSIFDRETPTMIT------KPKQVLGR 867
            .|:.|...|...:.| ||..||..:.....:..|    ..|...|.|....      |....|.:
Human   866 SLRKHEIIHSGEKPY-KCEECGKAFKWLSKLTVH----KVIHTAEKPCKCEECGKAFKHFSALRK 925

  Fly   868 YKDNSRENPKLPSPPPAPALAPAPPSPPACSSSAAASASSRSLKP----QPGGLPARPA--GLNT 926
            :|                 :......|..|.....|...|.:|..    ..|..|.:.|  |...
Human   926 HK-----------------IIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGKKPYKCAECGKAF 973

  Fly   927 LEDS-ISYHNAVDLDFITYFCPKCNQNFDSHAFWRKHIVEQHNFNSREGLNFRQIDNHHYLCLEC 990
            .:.| ::.|.|:......|.|.:|.::|::.:..:||.:    .::||.|         |.|.||
Human   974 KQSSHLTRHKAIHTGEKPYKCEECGKDFNNSSTLKKHKL----IHTREKL---------YKCEEC 1025

  Fly   991 YKRVTVTHTKGAIGQLQSHKFRHLPHRSFKCLTCGGEFVRKQMFFKHLNRDT-------NRCDN- 1047
            .|..      .....|..||..|...:.:||..||..|.......:|....|       ..||.
Human  1026 VKAF------NNFSALMKHKIIHTGEKPYKCEECGKAFKWSSKLTEHKVIHTGEKPCKCEECDKA 1084

  Fly  1048 -------RPHREF-DDDEPDQDTLLSTIYHLTCPQCGDNFKTHNKKEWREHINDHHGLTKLELLH 1104
                   |.|:.. ...:|.|           |.:||..|            |:...|||.:::|
Human  1085 FKHFSALRKHKVIHTGKKPYQ-----------CDECGKAF------------NNSSTLTKHKIIH 1126

  Fly  1105 MTKVGEDVYRCQDCDEELETNRQWVLQFHRFQHLPHAAYIRCKLC----KQSSADGADAVGELHS 1165
               .||..|:|::|.:..  ::..:|..|:..|.....| :|:.|    .|||
Human  1127 ---TGEKPYKCEECGKAF--SQSSILTKHKIIHSVEKPY-KCEECGKAFNQSS------------ 1173

  Fly  1166 LRELQQHIRKH---HPGLGDAEMISLIEQIIQDEKEQEEGTEQTNDGENPTGQDSGPYMPLPPHL 1227
                  |:.:|   |.|....:.....:..||........|..|.  |.||.....|.:...||.
Human  1174 ------HLTRHKTIHTGEKPYKCEECGKAFIQCSYLIRHKTIHTR--EKPTNVKKVPKLLSNPHT 1230

  Fly  1228 LDD 1230
            |.|
Human  1231 LLD 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368	4/20 (20%)
		C2H2 Zn finger	208..230	CDD:275368	9/21 (43%)
		C2H2 Zn finger	235..256	CDD:275368	5/20 (25%)
		C2H2 Zn finger	516..532	CDD:275368	6/15 (40%)
		C2H2 Zn finger	557..580	CDD:275368	6/22 (27%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		COG5236	<939..>1096	CDD:227561	36/172 (21%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368	2/5 (40%)
		C2H2 Zn finger	239..258	CDD:275368	4/27 (15%)
		COG5048	262..666	CDD:227381	89/446 (20%)
		C2H2 Zn finger	266..286	CDD:275368	9/21 (43%)
		C2H2 Zn finger	294..314	CDD:275368	4/20 (20%)
		C2H2 Zn finger	322..342	CDD:275368	2/19 (11%)
		C2H2 Zn finger	351..370	CDD:275368	2/18 (11%)
		zf-H2C2_2	363..386	CDD:290200	6/33 (18%)
		C2H2 Zn finger	378..398	CDD:275368	5/30 (17%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..454	CDD:275368	4/20 (20%)
		C2H2 Zn finger	462..482	CDD:275368	3/19 (16%)
		zf-H2C2_2	474..499	CDD:290200	4/26 (15%)
		C2H2 Zn finger	490..510	CDD:275368	9/21 (43%)
		zf-H2C2_2	502..527	CDD:290200	8/25 (32%)
		C2H2 Zn finger	518..538	CDD:275368	4/19 (21%)
		zf-H2C2_2	531..554	CDD:290200	2/22 (9%)
		C2H2 Zn finger	546..566	CDD:275368	1/19 (5%)
		C2H2 Zn finger	574..594	CDD:275368	5/24 (21%)
		C2H2 Zn finger	602..622	CDD:275368	3/19 (16%)
		COG5048	625..1123	CDD:227381	126/651 (19%)
		C2H2 Zn finger	630..650	CDD:275368	7/20 (35%)
		zf-H2C2_2	642..667	CDD:290200	9/37 (24%)
		C2H2 Zn finger	658..678	CDD:275368	6/22 (27%)
		zf-H2C2_2	670..695	CDD:290200	8/28 (29%)
		C2H2 Zn finger	686..706	CDD:275368	5/19 (26%)
		zf-H2C2_2	698..722	CDD:290200	4/23 (17%)
		C2H2 Zn finger	714..734	CDD:275368	4/22 (18%)
		C2H2 Zn finger	742..762	CDD:275368	0/19 (0%)
		C2H2 Zn finger	770..790	CDD:275368	3/45 (7%)
		C2H2 Zn finger	798..818	CDD:275368	5/19 (26%)
		C2H2 Zn finger	826..846	CDD:275368	6/20 (30%)
		C2H2 Zn finger	854..874	CDD:275368	5/21 (24%)
		zf-H2C2_2	866..890	CDD:290200	8/24 (33%)
		C2H2 Zn finger	882..902	CDD:275368	4/23 (17%)
		C2H2 Zn finger	910..930	CDD:275368	3/36 (8%)
		C2H2 Zn finger	938..958	CDD:275368	4/19 (21%)
		C2H2 Zn finger	966..986	CDD:275368	5/19 (26%)
		zf-H2C2_2	978..1003	CDD:290200	6/24 (25%)
		C2H2 Zn finger	994..1014	CDD:275368	5/23 (22%)
		C2H2 Zn finger	1022..1042	CDD:275368	7/25 (28%)
		zf-H2C2_2	1034..1058	CDD:290200	8/23 (35%)
		C2H2 Zn finger	1050..1070	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1078..1098	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1106..1126	CDD:275368	8/31 (26%)
		C2H2 Zn finger	1134..1154	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1162..1182	CDD:275368	7/37 (19%)
		C2H2 Zn finger	1190..1210	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840