Protein Alignment wkd and TBC1D5

DIOPT Version :9

• Sequence 1: NP_650089.1
• Gene: wkd / 41390
• FlyBaseID: FBgn0037917
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_001127853.1
• Gene: TBC1D5 / 9779
• HGNCID: 19166
• Length: 817
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 86/395 - (21%)
• Similarity: 140/395 - (35%)
• Gaps: 133/395 - (33%)

  Fly     8 LDTISLCSTVS-SCPDRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNY-KKI 70
            :|.:|..|..| ...::||     :||....:  |:....:..|:|      ..::::.|| ..|
Human    21 IDPLSSYSNKSGGDSNKNG-----RRTSSTLD--SEGTFNSYRKEW------EELFVNNNYLATI 72

  Fly    71 RDRCRKGIPKSVRP-----------------------------KAWF------------YLSGAY 94
            |   :|||...:|.                             :||:            .:.|..
Human    73 R---QKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQ 134

  Fly    95 LLKKKNP------NVYNELLEKPGNPTTIEEIKKDKHRQFPFHEM-FLDEQKVGQIELFNVLKAY 152
            .|...||      :::|:..:.....:.||:   |..|.||  || |..::.|.:| |.:||..|
Human   135 DLMINNPLSQDEGSLWNKFFQDKELRSMIEQ---DVKRTFP--EMQFFQQENVRKI-LTDVLFCY 193

  Fly   153 SIYNP----KVGFCQAQAPIAAFL------LMHL-----PAE-------------DAFWVFVSVC 189
            :..|.    |.|..:..|||...|      .:|.     |:|             ||:.||..:.
Human   194 ARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLM 258

  Fly   190 DVYLQDYFI--------------------------PGLEVIQNDAGILEGLLKKTCPPVYRHLQK 228
            :. .:.:|.                          |.:.::.....|.:.||||....:|.||.:
Human   259 ET-AEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNR 322

  Fly   229 HKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRV-----IFKVALVIIGASLSRHKVRK 288
            .::.|.:|...|......|..|.:.||.|||...|:|:.:     ||...|:.|..:|..... :
Human   323 LEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNY-Q 386

  Fly   289 TCTGL 293
            ||.||
Human   387 TCLGL 391

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	54/222 (24%)
TBC1D5	NP_001127853.1	TBC	79..381	CDD:214540	63/308 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810