DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and USP6

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001291213.1	Gene:	USP6 / 9098	HGNCID:	12629	Length:	1406	Species:	Homo sapiens

Alignment Length:	348	Identity:	97/348 - (27%)
Similarity:	151/348 - (43%)	Gaps:	58/348 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VSSCPDRNGFYGGFQRTDKPKEPLSKAQIIARE----KKWLYMIDNWSIYMSKNYKKIRDRCRKG 77
            ::|..||   :|....|:.|.....:|:.|.||    .||:.|:..|..|  |:..|:.||..||
Human    41 INSSIDR---FGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETY--KHSSKLIDRVYKG 100

  Fly    78 IPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTT--IEEIKKDKHRQFPFHEMFLDEQKV 140
            ||.::|...|..|.....:|.|||..| :::::.|..::  |..|..|.......|..|.|....
Human   101 IPMNIRGPVWSVLLNIQEIKLKNPGRY-QIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGA 164

  Fly   141 GQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQ 205
            .|.|||.:|.|||.|||:||:|:..:.|.|..|::||.|||||..|.:  :..:.:.:||..  .
Human   165 KQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQL--LASERHSLPGFH--S 225

  Fly   206 NDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWF-----LCAMTRTL-----------PWETL 254
            .:.|.::||         :..|:|.|......|.|.     ||....:|           .....
Human   226 PNGGTVQGL---------QDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLT 281

  Fly   255 LRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMR 319
            ||:||.:|.||.:|:..:..:    :|...:.|...|..|...|.||:        :|.....|.
Human   282 LRLWDVYLVEGEQVLMPITSI----ALKVQQKRLMKTSRCGLWARLRN--------QFFDTWAMN 334

  Fly   320 LNLRVEDFQIEHTRQKARRAKQK 342
                 :|..::|.|...::..:|
Human   335 -----DDTVLKHLRASTKKLTRK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	52/180 (29%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540	67/232 (29%)
		DUF4607	<332..407	CDD:292024	5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..380		1/5 (20%)
		UBP12	<528..1114	CDD:227847
		Peptidase_C19	533..>723	CDD:271592
		Peptidase_C19	<1023..1367	CDD:271592
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810