Protein Alignment wkd and TBC1D3F

DIOPT Version :10

• Sequence 1: NP_650089.1
• Gene: wkd / 41390
• FlyBaseID: FBgn0037917
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: NP_115634.3
• Gene: TBC1D3F / 84218
• HGNCID: 18257
• Length: 549
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 98/358 - (27%)
• Similarity: 150/358 - (41%)
• Gaps: 70/358 - (19%)

  Fly    28 GGFQRTDKPKEPLSKAQI------IAREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKA 86
            |....|:.|  ||:..:.      |:|:.||:.|:.:|..|  |:.:|:.||..||:|.::|...
Human    50 GIVHETELP--PLTAREAKQIRREISRKSKWVDMLGDWEKY--KSSRKLIDRAYKGMPMNIRGPM 110

  Fly    87 WFYLSGAYLLKKKNPNVYNELLEKPGNPTT--IEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVL 149
            |..|.....:|.|||..| :::::.|..::  |:.|.:|.......|..|.|.....|.||.::|
Human   111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHIL 174

  Fly   150 KAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDV---YLQDYFIPGLEVIQNDAGIL 211
            .||..|||:||:|:..:.|||..|::||.|||||..|.:...   .||.:..|....:|......
Human   175 LAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQ 239

  Fly   212 EGLLKKTCPPVYRHLQKH----KVEPL----LYMTDWFLCAMTRTLPWETLLRVWDCFLAEG--- 265
            |.::..:.|....|..|.    :..||    ..:.|.....:|        ||:||.:|.||
Human   240 EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLT--------LRLWDVYLVEGEQA 296

  Fly   266 ----IRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVED 326
                .|:.|||           .:.|.|.|..|...|             ...|..:....|.||
Human   297 LMPITRIAFKV-----------QQKRLTKTSRCGPWA-------------RFCNRFVDTWARDED 337

  Fly   327 FQIEHTRQKARRAKQK-------AQQEAESSGS 352
            ..::|.|...::..:|       |:.|..||.|
Human   338 TVLKHLRASMKKLTRKKGDVPPPAKPEQGSSAS 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	TBC	74..278	CDD:214540	65/223 (29%)
TBC1D3F	NP_115634.3	TBC	99..312	CDD:214540	65/232 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..425		6/21 (29%)
		PHA03381	<356..>468	CDD:177618	5/15 (33%)