DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Tbc1d9b

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001277689.1	Gene:	Tbc1d9b / 76795	MGIID:	1924045	Length:	1263	Species:	Mus musculus

Alignment Length:	406	Identity:	119/406 - (29%)
Similarity:	189/406 - (46%)	Gaps:	76/406 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 APRSLDT--------ISLCSTVSSCPD---------RNGFYGGFQRTDKPKEPLSKAQIIAREKK 51
            ||.||.|        .|..|.:||.|.         ..|....||: :.|.|.|.     |:..|
Mouse   417 APESLPTPQEASEPPASPSSPLSSPPSFSTQEIPTTSQGLLKVFQK-NSPMEDLG-----AKGAK 475

  Fly    52 WLYMIDNWSIYMSK------NYK--KIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELL 108
            .....::|:|:..:      .|:  |.|:...||||:|:|.:.|...|||:.....:|..|.||:
Mouse   476 EKMKEESWNIHFFEYGRGMCMYRTAKTRELVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELV 540

  Fly   109 EKPGNPTTI--EEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAF 171
            ||.....::  |||::|.||..|.|..|.:|  :|...|..||.||:..||.:|:|||...:.:.
Mouse   541 EKSLGKYSLATEEIERDLHRSMPEHPAFQNE--LGIAALRRVLTAYAFRNPTIGYCQAMNIVTSV 603

  Fly   172 LLMHLPAEDAFWVFVSVCDVYLQDYF---IPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEP 233
            ||::...|:|||:.|::|:..|.||:   :.|..|   |.||.|.|.:...|.:...:|:..|..
Mouse   604 LLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALV---DQGIFEELTRDVLPRLSEKMQELGVIS 665

  Fly   234 LLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLA 298
            .:.:: |||......:|:|:.:.:.|||..|||:||.:|||.::.|::.:   ...|....|.:.
Mouse   666 SISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANVEQ---LLDCNDEGEAMT 726

  Fly   299 VLRSPEEHIVEEEFI----------------------INNMMRL------NLRVEDFQIEHTRQK 335
            ||....:::|.::.|                      |.:::|:      |||.:|  ||..|.|
Mouse   727 VLGRYLDNVVNKQSISPPIPHLHALLTSGDDPPVEVDIFDLLRVSYEKFSNLRADD--IEQMRFK 789

  Fly   336 AR-RAKQKAQQEAESS 350
            .| :..|..:..|:.|
Mouse   790 QRLKVIQSLEDTAKRS 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	59/167 (35%)
Tbc1d9b	NP_001277689.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..449		10/31 (32%)
		TBC	506..716	CDD:214540	76/218 (35%)
		EFh	<856..907	CDD:298682
		EFh	887..912	CDD:197492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840