Protein Alignment wkd and TBC1D3H

DIOPT Version :10

• Sequence 1: NP_650089.1
• Gene: wkd / 41390
• FlyBaseID: FBgn0037917
• Length: 363
• Species: Drosophila melanogaster
• Sequence 2: XP_011523474.1
• Gene: TBC1D3H / 729877
• HGNCID: 30708
• Length: 610
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 103/383 - (26%)
• Similarity: 160/383 - (41%)
• Gaps: 76/383 - (19%)

  Fly     3 TAPRSLDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQI------IAREKKWLYMIDNWSI 61
            :|||.....:.||: |:.|       |...::....||:..:.      |:|:.||:.|:.:|..
Human    92 SAPRLGPLQAPCSS-SALP-------GLPYSETELPPLTAREAKQIRREISRKSKWVDMLGDWEK 148

  Fly    62 YMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTT--IEEIKKDK 124
            |  |:.:|:.||..||:|.::|...|..|.....:|.|||..| :::::.|..::  |:.|.:|.
Human   149 Y--KSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDI 210

  Fly   125 HRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC 189
            ......|..|.|.....|.||.::|.||..|||:||:|:..:.|||..|::||.|||||..|.:.
Human   211 SGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLL 275

  Fly   190 DV---YLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKH----KVEPL----LYMTDWFLC 243
            ..   .||.:..|....:|......|.::..:.|....|..|.    :..||    ..:.|....
Human   276 ASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISL 340

  Fly   244 AMTRTLPWETLLRVWDCFLAEG-------IRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLR 301
            .:|        ||:||.:|.||       .|:.|||           .:.|.|.|..|...|
Human   341 GLT--------LRLWDVYLVEGEQALMPITRIAFKV-----------QQKRLTKTSRCGPWA--- 383

  Fly   302 SPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQK-------AQQEAESSGS 352
                      ...|..:....|.||..::|.|...::..:|       |:.|..||.|
Human   384 ----------RFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSAS 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	TBC	74..278	CDD:214540	65/223 (29%)
TBC1D3H	XP_011523474.1	TBC	160..373	CDD:214540	65/232 (28%)
		PHA03381	<417..>529	CDD:177618	5/15 (33%)