DRSC/TRiP Functional Genomics Resources

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Protein Alignment wkd and Tbc1d10b

DIOPT Version :9

Sequence 1:NP_650089.1 Gene:wkd / 41390 FlyBaseID:FBgn0037917 Length:363 Species:Drosophila melanogaster
Sequence 2:NP_653105.3 Gene:Tbc1d10b / 68449 MGIID:1915699 Length:798 Species:Mus musculus


Alignment Length:388 Identity:159/388 - (40%)
Similarity:230/388 - (59%) Gaps:36/388 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LDTISLCS-TVSSCP--------------------DRNGFYGGFQRTDKPKEPLSKAQIIAREKK 51
            ||::||.| |:.|.|                    |:.||.||.|.:...:..:.......||.|
Mouse   256 LDSVSLMSGTLESLPDDVSSMGSDSEINGMALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELK 320

  Fly    52 WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTT 116
            ||.|..||..::|:.::|::.|||||||.|:|.|||.|||.:..|.::||..:.||....|:|..
Mouse   321 WLEMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAAGDPKW 385

  Fly   117 IEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDA 181
            ::.|:||.||||||||||......||.:|:.:||||:||.|..|:||||||:||.||||:|||.|
Mouse   386 LDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQA 450

  Fly   182 FWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMT 246
            ||..|.:||.||..|:..|||.||.|..|...||::..|..:|||::.:::|:||||:||:|...
Mouse   451 FWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRVSPLAHRHLRRQRIDPVLYMTEWFMCIFA 515

  Fly   247 RTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEE 311
            |||||.::|||||.|..||:::||:||||::..:|...:..::|.|:.||:..||:..:..::|:
Mouse   516 RTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQED 580

  Fly   312 FIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAESS--------GSGNGH---RRNMPTL 363
            |:::.:  .||.|.:..||  |:.|.:.|:..:...|..        ||...|   ||..|.|
Mouse   581 FLVHEV--TNLPVTEAWIE--RENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPL 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wkdNP_650089.1 RabGAP-TBC 114..277 CDD:366170 89/162 (55%)
Tbc1d10bNP_653105.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..79
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..211
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..250
TBC 343..548 CDD:214540 109/204 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 618..798 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 236 1.000 Domainoid score I2331
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D976276at2759
OrthoFinder 1 1.000 - - FOG0001498
OrthoInspector 1 1.000 - - otm43269
orthoMCL 1 0.900 - - OOG6_104218
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R540
SonicParanoid 1 1.000 - - X1223
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1211.810

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