DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and Tbc1d15

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_006514020.1	Gene:	Tbc1d15 / 66687	MGIID:	1913937	Length:	688	Species:	Mus musculus

Alignment Length:	367	Identity:	77/367 - (20%)
Similarity:	140/367 - (38%)	Gaps:	77/367 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GFQ---RTDKPKEPLSKAQIIAREKKWLYMID--NWSIYMSKNYKKIRDRCRKGIPKSVRPKAWF 88
            ||:   |.|..:.|:.:.:.....::|...:|  ...:.:....:||   .|.|:..|:|.:||.
Mouse   296 GFEVITRIDLGERPVVQRREPVSLEEWNKSLDPEGRLVAVESMKQKI---FRGGLSHSLRKQAWK 357

  Fly    89 YLSGAY-----------LLKKKNPNVYNELLEKPGNPTTIEE-----------IKKDKHRQFPFH 131
            :|.|.:           |.|:|....:...|:........|:           |:||.:|....:
Mouse   358 FLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSVSEAQEKRNSRLRDYRSLIEKDVNRTDRTN 422

  Fly   132 EMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAE-DAFWVFVSVCDVYLQD 195
            :.:..:...|.|.|.::|..|.:|:..:|:.|..:.:.:.||..:..| ||||.|.|..|...|:
Mouse   423 KFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQN 487

  Fly   196 Y--FIPGL--EVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLR 256
            :  .:.|:  ::||     |..||:........:|:......|.:...|.|....|...:..:||
Mouse   488 FEEQMQGMKTQLIQ-----LSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFSFLDILR 547

  Fly   257 VWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTG----LCETLAVLRSPEEHIVEEEFIIN-- 315
            :|:....|                       ..|..    ||  .|:|.|.::.|:.:.:..|
Mouse   548 LWEVMWTE-----------------------LPCKNFHLLLC--CAILESEKQQIMAKHYGFNEI 587

  Fly   316 ----NMMRLNLRVEDF--QIEHTRQKARRAKQKAQQEAESSG 351
                |.:.:.:.|||.  :.|....:..:.|:..|...|..|
Mouse   588 LKHINELSMKIDVEDILCKAEAISLQMAQCKELPQAVCEILG 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	39/178 (22%)
Tbc1d15	XP_006514020.1	DUF3548	10..211	CDD:371881
Tbc1d15	XP_006514020.1	TBC	343..578	CDD:214540	57/264 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810