DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc1d9

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_692034.2	Gene:	tbc1d9 / 563578	ZFINID:	ZDB-GENE-060810-33	Length:	1248	Species:	Danio rerio

Alignment Length:	268	Identity:	85/268 - (31%)
Similarity:	135/268 - (50%)	Gaps:	35/268 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 RTDKPKEPLSK-AQIIAREKKW------------LYMIDNWSIYMSKNYKKIRDRCRKGIPKSVR 83
            |...|:|...| |:...:|:.|            :|..|           |.:|...:|||:::|
Zfish   466 RRRSPEEFNPKLAKEFLKEQAWKNHFTEYGQGVCMYRTD-----------KTKDLVLQGIPENMR 519

  Fly    84 PKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTI--EEIKKDKHRQFPFHEMFLDEQKVGQIELF 146
            .:.|...|||......:|..|.:|:||......:  |||::|.||..|.|..|.:|  :|...|.
Zfish   520 GELWLLFSGAINEMATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNE--MGIAALR 582

  Fly   147 NVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYF---IPGLEVIQNDA 208
            .||.||:..||.:|:|||...:.:.||::...|:|||:.|::|:..|.||:   :.|..|   |.
Zfish   583 RVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVAMCERMLPDYYNTRVVGALV---DQ 644

  Fly   209 GILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVA 273
            |:.|.|.....|.:|..:|...|...:.:: |||......:|:|:.:.|.|||..|||:|||::|
Zfish   645 GVFEELAHVHVPQLYDCMQALGVISTISLS-WFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLA 708

  Fly   274 LVIIGASL 281
            |.::.|::
Zfish   709 LSVLDANI 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	60/167 (36%)
tbc1d9	XP_692034.2	PH-GRAM1_TCB1D9_TCB1D9B	154..252	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	301..396	CDD:270161
		TBC	510..720	CDD:214540	74/213 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840