DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc1d17

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_005164004.1	Gene:	tbc1d17 / 554092	ZFINID:	ZDB-GENE-050522-79	Length:	639	Species:	Danio rerio

Alignment Length:	457	Identity:	85/457 - (18%)
Similarity:	151/457 - (33%)	Gaps:	157/457 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YGGFQRTD--------KPKEPLSK------------------------AQIIAR-EKKWLYMIDN 58
            :|||.:..        .|:.||:.                        |::..| |.|....:||
Zfish   217 FGGFSKVTNFFRGALRNPESPLNNRSPQDPHFPHSADEEPGFELITCGAELGPRPEVKRGKPLDN 281

  Fly    59 WSIYMS-----KNYKKIRDRC-RKGIPKSVRPKAWFYLSGAY-----------LLKKKNPNV--- 103
            |..::.     .:.:|:::.. |.||...:|.:.|.:|.|.|           :|..|....
Zfish   282 WEQFLDPEGRVTDPQKVKELVFRGGIVPYLRKEVWKFLLGFYPWNSTTKEREDILMVKTDEYFRM 346

  Fly   104 --------------------YNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNV 148
                                |..|:|:..|.|       |:|..|     |...:..|...|.:|
Zfish   347 KVQWKSVSEEQEMRNSLFRGYRSLIERDVNRT-------DRHNSF-----FSGNENPGLTLLHDV 399

  Fly   149 LKAYSIYNPKVGFCQAQAPIAAFLLMHLPAE-DAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILE 212
            |..|.:||..:|:.|..:.:.:.||.....| ::||......|:..|: |....|.::.....|.
Zfish   400 LMTYCMYNFDLGYVQGMSDLLSPLLFVTQNEVESFWCLTGFMDLVHQN-FEESQEAMKQQLLQLS 463

  Fly   213 GLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVII 277
            .||:...|.:..:|.......|.:...|.|....|...:|.:|.:|:        |::
Zfish   464 LLLRALDPELCDYLDSQDSGSLCFCFRWLLIWFKREFSFEDILSLWE--------VLW------- 513

  Fly   278 GASLSRHKVRKTCTG--LCETLAVLRSPEEHIVEEEFIINNMMR----LNLRVE----------- 325
                    .|..|..  |....::|.|.:|.::......|::::    |.::::
Zfish   514 --------TRLPCENFHLLMACSILESQKEELIGSNHDFNSILKHINELTMKLDLQSVLCGAEAI 570

  Fly   326 DFQIEHTRQKARR-------------AKQKAQQEA--------ESSGSG-------NGH--RRNM 360
            ..|:.|.::.:.:             ::|....||        .|...|       |||  :|..
Zfish   571 YLQLTHCKELSPKVQEVLGLRIPSGSSEQSPDSEACEMDTLLSHSQARGATSCQPFNGHTPQRPP 635

  Fly   361 PT 362
            ||
Zfish   636 PT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	36/163 (22%)
tbc1d17	XP_005164004.1	DUF3548	5..211	CDD:192931
tbc1d17	XP_005164004.1	TBC	303..538	CDD:214540	56/270 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810