DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and TBC1D2

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001254500.1	Gene:	TBC1D2 / 55357	HGNCID:	18026	Length:	928	Species:	Homo sapiens

Alignment Length:	352	Identity:	99/352 - (28%)
Similarity:	159/352 - (45%)	Gaps:	43/352 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRD 72
            ::.:.|.:.:.:...|:....|.:..|:|          .|| :|..:.|   :..|...|::
Human   573 VEDLKLLAKIQALESRSHHLLGLEAVDRP----------LRE-RWAALGD---LVPSAELKQL-- 621

  Fly    73 RCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELL------EKPGNPTTIEEIKKDKHRQFPFH 131
             .|.|:|:..||:.|.:|....:.....|..|.|||      |.|    ...:|:.|.:|.||.:
Human   622 -LRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP----AARQIELDLNRTFPNN 681

  Fly   132 EMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAED-AFWVFVSVCDVYL-Q 194
            :.|.........:|..||.|:|..||.:|:||....:||..|:.|..|: |||..|::.:..: .
Human   682 KHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPA 746

  Fly   195 DYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWD 259
            ||:...|...|.|..:|:.||.:..|.:..||.:|.|:..|...:|||.....:|....||||||
Human   747 DYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWD 811

  Fly   260 CFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRV 324
            .||.||.:|:|:.||.|.  ..:..::.:...|| |....||      ...:.|.|:...:|:..
Human   812 AFLYEGTKVVFRYALAIF--KYNEKEILRLQNGL-EIYQYLR------FFTKTISNSRKLMNIAF 867

  Fly   325 ED---FQIEHTRQKARRAKQKAQQEAE 348
            .|   |:::..||  .|...:.:.|||
Human   868 NDMNPFRMKQLRQ--LRMVHRERLEAE 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	57/164 (35%)
TBC1D2	NP_001254500.1	Interaction with CADH1	1..169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		PH_TBC1D2A	47..147	CDD:269966
		PH	47..139	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..275
		Interaction with RAC1. /evidence=ECO:0000269\|PubMed:20116244	295..433
		TBC	625..837	CDD:214540	71/217 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810