DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and TBC1D8B

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_060222.2	Gene:	TBC1D8B / 54885	HGNCID:	24715	Length:	1120	Species:	Homo sapiens

Alignment Length:	299	Identity:	89/299 - (29%)
Similarity:	140/299 - (46%)	Gaps:	42/299 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NWSIYMSK--------NYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNP 114
            :|.|..::        ..||.||...:|||:::|.:.|...|||......||:.|.|::|:....
Human   460 SWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGT 524

  Fly   115 TTI--EEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLP 177
            ..:  |||::|..|..|.|..|  :...|...|..||.||:..|||:|:|||...:.:.||::..
Human   525 CNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAK 587

  Fly   178 AEDAFWVFVSVCDVYLQDYF---IPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTD 239
            .|:|||:.|:||:..|.|||   |.|..|   |..:.|.|::...|.:..|           |||
Human   588 EEEAFWLLVAVCERMLPDYFNRRIIGALV---DQAVFEELIRDHLPQLTEH-----------MTD 638

  Fly   240 ----------WFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLC 294
                      |||......||.|:.:.|.|||..:||:.|.::.|.|:..:|.:   ..||....
Human   639 MTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDK---LLTCKDDA 700

  Fly   295 ETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTR 333
            |.:..|....:::..::..:.:.::....|.|.:..|||
Human   701 EAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTR 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	59/177 (33%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159
		TBC	486..694	CDD:214540	74/226 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840