DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and TBC1D25

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001335191.1	Gene:	TBC1D25 / 4943	HGNCID:	8092	Length:	704	Species:	Homo sapiens

Alignment Length:	246	Identity:	60/246 - (24%)
Similarity:	104/246 - (42%)	Gaps:	35/246 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KP-KEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDRC-RKGIPKSVRPKAWFYLSGAY--- 94
            || |.|||.|:.      ..|:  |....:|:. :::|.|. ..|:..|:|...|.||...|
Human   209 KPFKPPLSDAEF------HTYL--NHEGQLSRP-EELRLRIYHGGVEPSLRKVVWRYLLNVYPDG 264

  Fly    95 --------LLKKKNPNVYNELLE---KPGNPTTIEEIK----KDKHRQFPFHEMFLDEQKVGQIE 144
                    .:|:|: ..|.:|..   :..||..:|.|:    ||..|....|..:...:....:.
Human   265 LTGRERMDYMKRKS-REYEQLKSEWAQRANPEDLEFIRSTVLKDVLRTDRAHPYYAGPEDGPHLR 328

  Fly   145 -LFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVY--LQDYFIPGLEVIQN 206
             |.::|..|::.:|:|.:||..:.:|:.:|..:..|.  ..||..|.:.  |...|.|....:..
Human   329 ALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEG--HAFVCFCGIMKRLAANFHPDGRAMAT 391

  Fly   207 DAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRV 257
            ....|:.||:...|..|::||:...:.|.:...|.|..:.|...::..||:
Human   392 KFAHLKLLLRHADPDFYQYLQEAGADDLFFCYRWLLLELKREFAFDDALRM 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	36/151 (24%)
TBC1D25	NP_001335191.1	TBC	241..470	CDD:214540	48/205 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810