DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc1d15

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_005159143.1	Gene:	tbc1d15 / 492676	ZFINID:	ZDB-GENE-041111-251	Length:	665	Species:	Danio rerio

Alignment Length:	320	Identity:	65/320 - (20%)
Similarity:	121/320 - (37%)	Gaps:	85/320 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IDNWSIYMS-----KNYKKIRDRCRK-GIPKSVRPKAWFYLSGAY----------LLKKKNPNV- 103
            ::.|:.|..     .|...::|...| |:..:||.:||.:|.|.:          ||:|:..:.
Zfish   298 MEEWAKYQDLEGRMTNLPHLKDAIFKGGLCHAVRKEAWKFLLGYFPWSSTHEERKLLQKRKTDEY 362

  Fly   104 -----------------------YNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIEL 145
                                   |..|:||..|.|       |::.:|     :......|.|.|
Zfish   363 FRMKLQWKSVSEEQERRNSRLRDYRSLIEKDVNRT-------DRNNKF-----YEGLDNPGLILL 415

  Fly   146 FNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAE-DAFWVFVSVCDVYLQDYFIPGLEVIQNDAG 209
            .::|..|.:|:..:|:.|..:.:.:.:|..:..| ||||.|||..| .:.:.|...::.::....
Zfish   416 HDILMTYCMYDFDLGYVQGMSDLLSPILFVMENEVDAFWCFVSFMD-EMHENFEEQMQGMKTQLI 479

  Fly   210 ILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVAL 274
            .|..||:......:.:|:......|.:...|.|....|.|.::.:||:|:...
Zfish   480 QLSTLLRLLDLAFWNYLEAQDSGYLYFCFRWLLIRFKRELHFQDVLRLWEVMW------------ 532

  Fly   275 VIIGASLSRHKVRKTCTG--LCETLAVLRSPEEHIVEEEFIIN------NMMRLNLRVED 326
                       .|..|..  |....|:|.|.::.|::.::..|      |.:.:.|.:|:
Zfish   533 -----------TRLPCQNFHLLVCCAILDSEKQKIMDRKYGFNEILKHINELSMKLDIEE 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	34/163 (21%)
tbc1d15	XP_005159143.1	DUF3548	4..220	CDD:192931
tbc1d15	XP_005159143.1	TBC	322..557	CDD:214540	56/270 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810