DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and CG12241

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster

Alignment Length:	332	Identity:	83/332 - (25%)
Similarity:	148/332 - (44%)	Gaps:	49/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRNGFYGGFQRTDKPKEPLSKAQII-----AREK-KWLYMID----------NWS--IYMSKNYK 68
            |..||  ..:..|.|::..:|...|     |::: :|:..::          :|.  ..|....:
  Fly    93 DEFGF--RVEEEDGPEQSSNKLLSIPFVEDAQQRLQWIAHLEFSHNKEAAELSWEHVDVMLPRTE 155

  Fly    69 KIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNP--TTIEEIKKDKHRQFPFH 131
            |:|:..|:|||.::|.:.|..||||...|:|:...|:::::...|.  .|.::|:||..|..|.:
  Fly   156 KLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQIEKDLLRILPTN 220

  Fly   132 EMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC-DVYLQD 195
            ..|.:....|...|..:|:..:...|.:|:||....|.|.||:.:..|:|||:..::. |:....
  Fly   221 ACFSNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLFMEEENAFWMMATIVEDLLPAS 285

  Fly   196 YFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDC 260
            |:...|..||.|..::..|:......|...|:||.:|..|....|||......:..:.|:|:||.
  Fly   286 YYSSTLLGIQADQRVMHTLIANYLSSVDESLRKHDIELSLITLHWFLTLFANVVHMKILVRIWDW 350

  Fly   261 FLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEE---HIVEEEFIINNMMRLNL 322
            |..||..|:|::                       ||.:|:..|:   |:.....|.|::..:..
  Fly   351 FFYEGSIVLFQL-----------------------TLGMLKVKEQDLKHLENSAQIFNSLSDIPG 392

  Fly   323 RVEDFQI 329
            .|.|.::
  Fly   393 EVTDVEV 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	47/165 (28%)
CG12241	NP_650432.1	TBC	161..375	CDD:214540	65/236 (28%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456629
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.870