DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and sgsm3

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_998495.1	Gene:	sgsm3 / 406635	ZFINID:	ZDB-GENE-040426-2635	Length:	755	Species:	Danio rerio

Alignment Length:	313	Identity:	91/313 - (29%)
Similarity:	136/313 - (43%)	Gaps:	49/313 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DRCRK----GIPKSVRPKAWFYLSGAYLLKKKNPNV-YNELLEKPGN--PTTIEEIKKDKHRQFP 129
            ||.|.    |||.|:||:.|..|||| |.||:..:: |.|:::...|  .|..::|:||..|..|
Zfish   106 DRLRSLVLGGIPHSMRPQLWMRLSGA-LQKKRTSDISYREIVKNSSNDDTTAAKQIEKDLLRTMP 169

  Fly   130 FHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC-DVYL 193
            .:..|.....||..:|..||:..:...|.:|:||....:.:.||:.|..|||.|:..::. |:..
Zfish   170 TNACFNTLTSVGVPKLRRVLRGLAWLYPDIGYCQGTGMVVSCLLLFLEEEDALWMMCALIEDLLP 234

  Fly   194 QDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVW 258
            ..||...|..:|.|..:|..|:.:..|.:.:.||:|.:|..|....|||.|....:....|||:|
Zfish   235 PSYFSSTLLGVQTDQRVLRQLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIRILLRIW 299

  Fly   259 DCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEE---FIINNMMRL 320
            |....||..|:|:|                       ||.:|:..|:.:|..|   .|.|.:..|
Zfish   300 DLLFYEGSMVLFQV-----------------------TLGMLKIKEDELVSSENSASIFNTLSDL 341

  Fly   321 NLRVED------------FQIEHTRQKARRAKQKAQQEAESS--GSGNGHRRN 359
            ..::||            ..:........|.|..|...||.:  .|.|.|..|
Zfish   342 PSQLEDGAAVLGEAVRLAGSLSQENLDTHRHKHLAYILAEQAQLNSNNSHSLN 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	51/163 (31%)
sgsm3	NP_998495.1	TBC	112..326	CDD:214540	72/237 (30%)
		SH3_SGSM3	488..540	CDD:212747
		RUN	567..720	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840