DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and GAPcenA

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster

Alignment Length:	374	Identity:	106/374 - (28%)
Similarity:	172/374 - (45%)	Gaps:	40/374 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MATAPRSLDTISLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIARE------KKWLYMIDNW 59
            |....|.:.:.|:.|....||......|     |:|.  ||....::::      .:|..::..|
  Fly   580 MNNLSRIVRSSSIASIEDDCPSDYSSDG-----DEPL--LSGTGEVSKDCSQDTLDEWDPILREW 637

  Fly    60 SIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDK 124
            .  ..|..|.:....|.|:|:::|.|.|..|:......:.| :.|..|:.|.....|:  |::|.
  Fly   638 D--SEKRPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITKETKCETV--IQRDI 697

  Fly   125 HRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC 189
            ||.||.|:.|.:....||..||.|.|||::::.:||:||..:.|||.||:|:|.||||.|.|::.
  Fly   698 HRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEEDAFCVLVALM 762

  Fly   190 -DVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWET 253
             |..|:|.:..|.||:......||.|:|...|.::.|.....:|..:|.:.|||...|...|...
  Fly   763 YDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMYASQWFLTLYTARFPLCF 827

  Fly   254 LLRVWDCFLAEGIRVIFKVALVIIGASLS--------------RHKVRKTCTGLCETLAVLRSPE 304
            :..|.|.||.:|:.|:|:||:.::....|              |..:.|.|....:...|::...
  Fly   828 VFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGILKYFRVTLPKKCRSSSQARKVMKQAC 892

  Fly   305 EHIV------EEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEA 347
            |..:      ||||::....:..|. ::.||...|....|.|.:|:.:|
  Fly   893 ERKIKKLKQYEEEFLLKKQHKERLE-KEAQIYENRFGEERRKMQAEIDA 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	62/163 (38%)
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	74/210 (35%)
		Phage_Gp23	<914..991	CDD:287621	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456587
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840