DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_006538109.1	Gene:	Tbc1d2 / 381605	MGIID:	2652885	Length:	923	Species:	Mus musculus

Alignment Length:	374	Identity:	105/374 - (28%)
Similarity:	165/374 - (44%)	Gaps:	65/374 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DTISLCSTVSSCPDRNGFYGGFQRTDKPKEP---LSKAQ--------IIAREKKWLYMIDNWS-- 60
            |::.| |.||...|    ||.....|...|.   |:|.|        ::|.|.....:.|.|:
Mouse   545 DSVGL-SPVSEYDD----YGFLTVPDYEMEDLKLLAKIQALEVRSHHLLAHEAVERPLRDRWATL 604

  Fly    61 --IYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELL------EKPGNPTTI 117
              :..|...|::   .|.|:|:..||:.|.:|....:...:.|..|.|||      |.|    ..
Mouse   605 TELTPSAELKQL---LRAGVPREHRPRVWRWLVHRRVRHLQAPGCYQELLARGRACEHP----AA 662

  Fly   118 EEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAED-A 181
            .:|:.|.:|.||.::.|.........:|..||.|:|..||.:|:||....:||..|:.|..|: |
Mouse   663 RQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESA 727

  Fly   182 FWVFVSVCDVYL-QDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAM 245
            ||..|::.:..| .:|:...|...|.|..:|:.||.:..|.:..||.:|:|:..|...:|||...
Mouse   728 FWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVF 792

  Fly   246 TRTLPWETLLRVWDCFLAEGIRVIFKVALVI----------IGASLSRHKVRKTCT-GLCETLAV 299
            ..:|..:.||||||.||.||.:|:|:.||.|          :..||..::..:..| .:|::..:
Mouse   793 ADSLISDILLRVWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICDSRKL 857

  Fly   300 LRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAE 348
            :          ....|:|       ..|.::..||  .||..:.:.|||
Mouse   858 M----------SIAFNDM-------NPFPMKQLRQ--LRAAHRERLEAE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	58/174 (33%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK14951	<192..404	CDD:237865
		COG4913	<300..>565	CDD:227250	8/24 (33%)
		TBC	620..832	CDD:214540	71/215 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810