DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wkd and TBC1D10C

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001356427.1	Gene:	TBC1D10C / 374403	HGNCID:	24702	Length:	454	Species:	Homo sapiens

Alignment Length:	367	Identity:	151/367 - (41%)
Similarity:	213/367 - (58%)	Gaps:	27/367 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRNGFYGGFQRTDKPKEPLSKAQII-AREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPK 85
            ||.||.||......|..|  .|.:| .||.||:.|..:|...||:.|||::.:||||||.::|.:
Human    38 DRYGFIGGSSAEPGPGHP--PADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRAR 100

  Fly    86 AWFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLK 150
            .|..|.||::.:|.:|..|.||.|.||:|..:|.|.:|.|||||.||||:..|..||..|..|||
Human   101 CWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLK 165

  Fly   151 AYSIYNPKVGFCQAQAPIAAFLLMHLPAE--------DAFWVFVSVCDVYLQDYFIPGLEVIQND 207
            ||::|.|:.|:||||.|:||.||||||.|        :|||..|.:|:|||..|:.|.:|.::.|
Human   166 AYTLYRPEQGYCQAQGPVAAVLLMHLPPEACALPLPQEAFWCLVQICEVYLPGYYGPHMEAVRLD 230

  Fly   208 AGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKV 272
            |.:...||::..|.|::|||:..|.||||:.:||||...|:||:.|:|||||.||:||.||:|:|
Human   231 AEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRV 295

  Fly   273 ALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIE------- 330
            .|.::..:|...:.|..|.||.|||..||:.....::||..::.:..:.|...|.|.|
Human   296 GLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEAFMSQVHSVVLSERDLQREIKAQLAQ 360

  Fly   331 --------HTRQKARRAKQKAQQEAES-SGSGNGHRRNMPTL 363
                    ..|.:.|.|..:|..||:. :|...|.:..:|.:
Human   361 LPDSAPGPPPRPQVRLAGAQAIFEAQQLAGVRRGAKPEVPRI 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	86/170 (51%)
TBC1D10C	NP_001356427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		8/21 (38%)
		TBC	89..302	CDD:214540	105/212 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..454		2/11 (18%)
		Interaction with calcineurin	414..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	236	1.000	Domainoid score	I2344
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2584
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46720
OrthoDB	1	1.010	-	-		D309166at33208
OrthoFinder	1	1.000	-	-		FOG0001498
OrthoInspector	1	1.000	-	-		otm41204
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1223
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980