DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc-10

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_497310.2	Gene:	tbc-10 / 3564790	WormBaseID:	WBGene00019915	Length:	445	Species:	Caenorhabditis elegans

Alignment Length:	323	Identity:	136/323 - (42%)
Similarity:	198/323 - (61%)	Gaps:	12/323 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 DRNGFYGGFQRTDKPKEPLSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKA 86
            ||.||:....:...|  |:....:..|||||:.|:|||..:|.:.::.:::|||||||.|:|.:|
Worm   121 DRFGFFTIQNKCSTP--PIDSKILRRREKKWIQMLDNWRYFMDEKFELVKNRCRKGIPPSLRGRA 183

  Fly    87 WFYLSGA-YLLK-KKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKV---GQIELF 146
            |.||||| |.:: ..|..|::..:::.|:|...::|:||..||||.||||....|.   |:.:||
Worm   184 WKYLSGATYQMEVSSNRFVFDYCVKQAGDPKWNDDIQKDLSRQFPEHEMFARVGKYGNNGKNDLF 248

  Fly   147 NVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQNDAGIL 211
            ::|||::|.:|:.|:||.||||||.||||:|..|||:.||.:|..||..|:..|||.:|.|..||
Worm   249 DLLKAWTILHPEEGYCQGQAPIAAVLLMHMPVRDAFYCFVQICHKYLPGYYSSGLEAVQTDGDIL 313

  Fly   212 EGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVI 276
            ..|:|......|||.:.:.|:|.|||.:||:|...|||||.|:|||||.||.||::::||||||:
Worm   314 TKLIKDRSKLTYRHFKANGVDPALYMIEWFMCCFCRTLPWPTVLRVWDMFLCEGVKILFKVALVL 378

  Fly   277 IGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEH-----TRQ 334
            :...:......|....:...:..||:....|:||||::..:...||...|.:..|     |||
Worm   379 LKFGIGTPSQIKQYPDMPAIVTRLRNLPVEIMEEEFLVQKISETNLNDADMEKLHFGAMKTRQ 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	85/165 (52%)
tbc-10	NP_497310.2	TBC	171..380	CDD:214540	104/208 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165743
Domainoid	1	1.000	200	1.000	Domainoid score	I1775
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I1890
Isobase	1	0.950	-	0	Normalized mean entropy	S2353
OMA	1	1.010	-	-		QHG46720
OrthoDB	1	1.010	-	-		D309166at33208
OrthoFinder	1	1.000	-	-		FOG0001498
OrthoInspector	1	1.000	-	-		oto17404
orthoMCL	1	0.900	-	-		OOG6_104218
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R540
SonicParanoid	1	1.000	-	-		X1223
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.790