DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and tbc

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	235	Identity:	52/235 - (22%)
Similarity:	96/235 - (40%)	Gaps:	25/235 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 NPNVY-NELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQ 163
            |..|| :||||:.|  ..:..|:||..|....:..|.:|   ...:|.||:..|...:..||:.|
  Fly   927 NGGVYSSELLEQFG--LNLHRIEKDVQRCDRNYWYFANE---NLDKLRNVISTYVWEHLDVGYMQ 986

  Fly   164 AQAPIAAFLLMHLPAED-AFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQ 227
            ....:.|.||:....|. ::..|..:.:..::::  |....:......:..|::.....:|..:.
  Fly   987 GMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF--PSGGAMDMHFANMRSLIQILDSEMYDLMD 1049

  Fly   228 KHKVEPLLYMT-DWFLCAMTRTLPWETLLRVWDCF-----LAEGIRVIF-KVAL------VIIGA 279
            .:......|.. .|||....|.|.::.:...|:..     :|.|..|:| .:||      :|:..
  Fly  1050 SNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSN 1114

  Fly   280 SLSRHKVRKTCTGLCE---TLAVLRSPEEHIVEEEFIINN 316
            |:....|.|....:.|   ..:||:.....:::.:.||.|
  Fly  1115 SMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIEN 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	34/176 (19%)
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	36/166 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930