DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and CG4041

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_572197.4	Gene:	CG4041 / 31422	FlyBaseID:	FBgn0029736	Length:	819	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	78/350 - (22%)
Similarity:	136/350 - (38%)	Gaps:	64/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 FQRTDKPKEP------LSKAQIIAREKKWLYMIDNWSIY--MSKNYKKIRDRCRK----GIPKSV 82
            |.....|:.|      |.:..::.|||...|......::  :.:.|....::.::    .:|..:
  Fly   372 FPLLHSPRFPAHFARELQELPLVIREKDIEYQFQRVRLFARLLQGYPHTAEQLQREAAVDVPPLL 436

  Fly    83 RPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFN 147
            |...|     |.||:.. ||.....::|..:.:|..:|:.|..|...:.|:.....  |..:|..
  Fly   437 RGPIW-----AALLEVV-PNGSYAKIDKFTSTSTDRQIEVDIPRCHQYDELLSSPD--GHRKLRR 493

  Fly   148 VLKAYSIYNPKVGFCQAQAPIAA-FLLMHLPAED-AFWVFVSVCDVYLQDYFIPGLEVIQNDAGI 210
            :|||:...:|:..:.|....:.| ||.::...|: ||.........|||.:|:.     .|.|.|
  Fly   494 LLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFIPKYLQWFFLK-----DNSAVI 553

  Fly   211 LEGLLKKTC------PPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWD-CFLAEGIRV 268
            .|.|.|.:.      |.:.:||......|.|:...|||...:...|...:|.:|| ..|.:....
  Fly   554 KEYLSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHVFPLHKILHLWDKLMLGDSSYP 618

  Fly   269 IFKVALVIIGASLSRHKVRKT--------CTGLCETL-------AVLRSPEEHIVEEEFIINNMM 318
            :|      ||.::.| ::|.|        |..|...|       .||.|.:.:....:.|.:...
  Fly   619 LF------IGIAILR-QLRSTLLTSGFNECILLFSDLPDIVMDGCVLESQKMYEATPKSITHRQH 676

  Fly   319 RLNLR--------VEDFQIEHTRQK 335
            .|.|:        |.|.:::|.:|:
  Fly   677 ALRLQPPQALDIGVADVELKHLQQE 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	42/171 (25%)
CG4041	NP_572197.4	PKc_like	45..272	CDD:304357
		TBC	432..634	CDD:214540	56/221 (25%)
		RHOD_Kc	706..810	CDD:238783
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456522
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030