DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_006255308.1	Gene:	Tbc1d9 / 304645	RGDID:	1308221	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	303	Identity:	97/303 - (32%)
Similarity:	149/303 - (49%)	Gaps:	45/303 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 STVSSCPDR--------------NG------------FYGGFQRTDKPKEPLSK-AQIIAREKKW 52
            |.|||.|.|              ||            .|    |...|:|...| |:...:|:.|
  Rat   427 SLVSSSPQRSTSSDADGERPFNLNGNSVPTATQTLMTMY----RRRSPEEFNPKLAKEFLKEQAW 487

  Fly    53 LYMIDNW--SIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPT 115
            ......:  .|.|.:. :|.|:...||||:.:|.:.|..||||...|..:|..|.:|:||.....
  Rat   488 KIHFAEYGQGICMYRT-EKTRELVLKGIPERMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKY 551

  Fly   116 TI--EEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPA 178
            .:  |||::|.||..|.|..|.:|  :|...|..||.||:..||.:|:|||...:.:.||::...
  Rat   552 NLATEEIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKE 614

  Fly   179 EDAFWVFVSVCDVYLQDYF---IPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDW 240
            |:|||:.|::|:..|.||:   :.|..|   |.|:.|.|.:...|.:|..:|...|...:.:: |
  Rat   615 EEAFWLLVALCERMLPDYYNTRVVGALV---DQGVFEELARDYVPQLYDCMQDLGVISTISLS-W 675

  Fly   241 FLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSR 283
            ||......:|:|:.:.|.|||..|||:|||::||.::.|::.:
  Rat   676 FLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	60/167 (36%)
Tbc1d9	XP_006255308.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161
		TBC	510..720	CDD:214540	77/215 (36%)
		EFh	<891..921	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810