DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Tbc1d30

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_038936067.1	Gene:	Tbc1d30 / 299824	RGDID:	1305255	Length:	946	Species:	Rattus norvegicus

Alignment Length:	257	Identity:	72/257 - (28%)
Similarity:	105/257 - (40%)	Gaps:	53/257 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RCRKGIPKSVRPKAWFYLSGAYL------LKKKNPNVYNELLEKPGNPTTIEEIKKDKHR----- 126
            |...||||..|.|.|..|:..||      ..|.....:|| ...|.:.:...:|.||.||
  Rat   271 RLSTGIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNE-RSNPDDDSMGIQIVKDLHRTGCSS 334

  Fly   127 ---QFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLL--MHLPAEDAFWVFV 186
               |         |.:..::.|..||.||:.:|..||:||....:||.:|  |.....||..:.:
  Rat   335 YCGQ---------EAEQDRVVLKRVLLAYARWNKNVGYCQGFNILAALILEVMEGNEGDALKIMI 390

  Fly   187 SVCDVYL-QDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHK----------VEPLL---YM 237
            .:.|..| :.||:..|..:..|..:...||:...|.:.:||...:          .||.|   :.
  Rat   391 YLIDKVLPESYFVNNLRALSVDMAVFRDLLRLKLPELSQHLDTLQRTSNKESGGGYEPPLTNVFT 455

  Fly   238 TDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVI---IGASLSRHKVRKTCTGLCET 296
            ..|||......||..|:|::||....||..:|.:|:|.|   :|..:.       |   |||
  Rat   456 MQWFLTLFATCLPNHTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIE-------C---CET 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	52/189 (28%)
Tbc1d30	XP_038936067.1	TBC	273..494	CDD:214540	65/230 (28%)
Tbc1d30	XP_038936067.1	DUF4682	663..791	CDD:406220
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910