DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	XP_006496938.1	Gene:	Rabgap1l / 29809	MGIID:	1352507	Length:	1051	Species:	Mus musculus

Alignment Length:	322	Identity:	86/322 - (26%)
Similarity:	146/322 - (45%)	Gaps:	34/322 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAY----LLKKKNPNVYNELLEKPG 112
            |..::..|...:....|.:....:.|:|:::|.:.|..|:|.:    :|.|     |..|:.|..
Mouse   513 WGELLGRWHNNLGGRPKGLFTLVKSGVPEALRAEVWQLLAGCHDNQEMLDK-----YRILITKDS 572

  Fly   113 NPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLP 177
            ...::  |.:|.||.||.|:.|.|....||..|:.:.||||:::..:|:||.|:.:||.||:|:|
Mouse   573 AQESV--ITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMP 635

  Fly   178 AEDAFWVFVSVCDVY-LQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWF 241
            .|.||.|.|::...| |:|.:....|.:......||.|:::..|.:|.|.....:|..:|.:.||
Mouse   636 EEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWF 700

  Fly   242 LCAMTRTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASL--------------------SRHKV 286
            |...|...|...:..:.|..|.||:.:||.|||.::..|.                    .|::.
Mouse   701 LTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRA 765

  Fly   287 RKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVEDFQIEHTRQKAR--RAKQKAQQE 346
            .:....|.|....::.|.:.:.:.|.....|....|:.||....:.|:..|  .|..:.:||
Mouse   766 EENARRLMEQACNIKVPTKKLKKYEKEYQAMRENQLQQEDPMDRYKRENRRLQEASMRLEQE 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	57/163 (35%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:372133
		RabGAP-TBC	541..744	CDD:366170	67/209 (32%)
		Smc	<814..>1019	CDD:224117	4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810