DRSC/TRiP Functional Genomics Resources

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Protein Alignment wkd and TBC1D10B

DIOPT Version :9

Sequence 1:NP_650089.1 Gene:wkd / 41390 FlyBaseID:FBgn0037917 Length:363 Species:Drosophila melanogaster
Sequence 2:NP_056342.3 Gene:TBC1D10B / 26000 HGNCID:24510 Length:808 Species:Homo sapiens


Alignment Length:388 Identity:160/388 - (41%)
Similarity:230/388 - (59%) Gaps:36/388 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 LDTISLCS--------TVSSC-------------PDRNGFYGGFQRTDKPKEPLSKAQIIAREKK 51
            ||::||.|        .|||.             .|:.||.||.|.:...:..:.......||.|
Human   270 LDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELK 334

  Fly    52 WLYMIDNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPTT 116
            ||.|..||..::|:.::|::.|||||||.|:|.|||.|||.:..|.::||..:.||...||:|..
Human   335 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKW 399

  Fly   117 IEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDA 181
            ::.|:||.||||||||||......||.:|:.:||||:||.|..|:||||||:||.||||:|||.|
Human   400 LDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQA 464

  Fly   182 FWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMT 246
            ||..|.:||.||..|:..|||.||.|..|...||::..|..:|||::.:::|:||||:||:|...
Human   465 FWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFA 529

  Fly   247 RTLPWETLLRVWDCFLAEGIRVIFKVALVIIGASLSRHKVRKTCTGLCETLAVLRSPEEHIVEEE 311
            |||||.::|||||.|..||:::||:||||::..:|...:..::|.|:.||:..||:..:..::|:
Human   530 RTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQED 594

  Fly   312 FIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAESS--------GSGNGH---RRNMPTL 363
            |:::.:  .||.|.:..||  |:.|.:.|:..:...|..        ||...|   ||..|.|
Human   595 FLVHEV--TNLPVTEALIE--RENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPL 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wkdNP_650089.1 RabGAP-TBC 114..277 CDD:366170 89/162 (55%)
TBC1D10BNP_056342.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 60..225
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..264
TBC 357..562 CDD:214540 110/204 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 629..808 7/25 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 236 1.000 Domainoid score I2344
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 312 1.000 Inparanoid score I2584
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D309166at33208
OrthoFinder 1 1.000 - - FOG0001498
OrthoInspector 1 1.000 - - otm41204
orthoMCL 1 0.900 - - OOG6_104218
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R540
SonicParanoid 1 1.000 - - X1223
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.860

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