DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Tbc1d17

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001036120.1	Gene:	Tbc1d17 / 233204	MGIID:	2449973	Length:	645	Species:	Mus musculus

Alignment Length:	307	Identity:	67/307 - (21%)
Similarity:	119/307 - (38%)	Gaps:	61/307 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DNWSIYMS-----KNYKKIRDRC-RKGIPKSVRPKAWFYLSGAYL------------LKKKNPNV 103
            :.|:.|:.     :|..::::|. ..|:...:|.:||.:|.| ||            ::||....
Mouse   284 EEWNRYVGPEGRLQNVPELKNRIFSGGLSPGLRREAWKFLLG-YLSWESSAEEHKAHVRKKTDEY 347

  Fly   104 Y----------------NELLEKPGNPTTIEEIKKDKHRQFPFHEMFLDEQKVGQIELFNVLKAY 152
            :                |.||.  |..:.||   :|..|....::.:...:..|...|.::|..|
Mouse   348 FRMKLQWKSVSAEQERRNSLLH--GYRSLIE---RDVSRTDRTNKFYEGPENPGLSLLHDILLTY 407

  Fly   153 SIYNPKVGFCQAQAPIAAFLLMHLPAE-DAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLK 216
            .:|:..:|:.|..:.:.:.:|..:..| ||||.|....:: :...|....|.::...|.|..||:
Mouse   408 CMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFMEL-VHGNFEESQETMKRQLGQLLLLLR 471

  Fly   217 KTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLA--EGIRVIFKVALVIIGA 279
            ....|:...|.......|.:...|.|....|..|:..:||:|:....  .|..:...||..|:
Mouse   472 VLDQPLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAIL-- 534

  Fly   280 SLSRHKVRKTCTGLCETLAVLRSPEEHIVEEEFIINNMMRLNLRVED 326
            .:.|..:..:..|..|.|       :||        |.:.:.|.|||
Mouse   535 DMERDTLMLSGFGSNEIL-------KHI--------NELTMKLSVED 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	37/165 (22%)
Tbc1d17	NP_001036120.1	DUF3548	3..217	CDD:192931
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..85
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		4/24 (17%)
		TBC	307..542	CDD:214540	53/243 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810