DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wkd and Rabgap1

DIOPT Version :9

Sequence 1:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster
Sequence 2:	NP_001349885.1	Gene:	Rabgap1 / 227800	MGIID:	2385139	Length:	1064	Species:	Mus musculus

Alignment Length:	376	Identity:	99/376 - (26%)
Similarity:	167/376 - (44%)	Gaps:	46/376 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SLCSTVSSCPDRNGFYGGFQRTDKPKEPLSKAQIIARE------KKWLYMIDNWSIYMSKNYKKI 70
            |..|.:.|.|:.:      :..|..:..||....:::|      :.|..::..|.:.:|...|::
Mouse   496 SQSSMIPSPPEDD------EEEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLSVRPKQL 554

  Fly    71 RDRCRKGIPKSVRPKAWFYLSGA----YLLKKKNPNVYNELLEKPGNPTTIEEIKKDKHRQFPFH 131
            ....|.|:|:::|.:.|..|:|.    :|::|     |..|:.|.....:  .|.:|.:|.||.|
Mouse   555 SSLVRSGVPEALRGEVWQLLAGCHNNDHLVEK-----YRILITKESPQDS--AITRDINRTFPAH 612

  Fly   132 EMFLDEQKVGQIELFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVC-DVYLQD 195
            :.|.|....||..|:.:.||||:|:.::|:||.|:.:||.||:|:|.|.||.|.|.:. |..|::
Mouse   613 DYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRE 677

  Fly   196 YFIPGLEVIQNDAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDC 260
            .|....|.:......||.|:::..|.:|.|.....:|..:|.:.|||...|...|...:..:.|.
Mouse   678 LFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDL 742

  Fly   261 FLAEGIRVIFKVALVIIGASL--------------------SRHKVRKTCTGLCETLAVLRSPEE 305
            .|.|||.|||.|||.::..|.                    .|::..:....|.|.....:..::
Mouse   743 LLCEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKRLMELACNTKISQK 807

  Fly   306 HIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQKAQQEAESSGSGNGH 356
            .:.:.|...:.|.....:.|| .||...::.||. |:|....|.......|
Mouse   808 KLKKFEKEYHTMREQQAQQED-PIERFERENRRL-QEANMRLEQENDDLAH 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	59/163 (36%)
Rabgap1	NP_001349885.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..101
		PTB_Rab6GAP	140..268	CDD:269922
		DUF3694	302..432	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..520		6/29 (21%)
		TBC	558..767	CDD:214540	72/215 (33%)
		ERM	789..1013	CDD:330563	14/70 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810